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Cancer Research Solutions

Helping scientists unravel the complexities of cancer

Cancer is not a single disease, but a complex group of hundreds of separate diseases – and the global incidences of these cancers are increasing all the time. There is an increasing urgency to understand the biology of cancer and translate that information to clinical outcomes to better treat and ultimately eradicate the disease.

We are committed to helping you explore and unravel the complexities of cancer and translate your findings into more effective treatments with a diverse range of solution tools to further your research. Whether you are studying cancer at the genomic level, elucidating cellular pathways, determining a compound’s effects on 3D tumor models, studying tumor growth in animal models, or examining the tumor and its microenvironment. We know that the next big cancer breakthrough will begin with research. And that research begins with you.

For research purposes only. Not for use in diagnostic procedures.

Explore Our Solutions

Genomics Solutions Cancer Research

Advances in genomic technologies has improved our understanding of the biology of cancer. Genomic approaches to cancer research can be use to study its mechanisms, improve biomarker discovery, and help drive targeted therapeutic discovery leading to new methods for diagnosing and treating the disease.

Our genomics solutions for cancer research cover multiple application areas including; DNA/RNA analysis, Nucleic Acid Isolation, CRISPR Analysis, and more. Our broad range of solutions are designed to improve the efficiency of your genomic cancer research from extraction to analysis.

  • Nucleic acid isolation
  • Whole genome sequencing
  • Exome sequencing
  • Targeted amplicon sequencing
  • Transcriptomics
  • Epigenomics
  • cfDNA research
  • PCR/qPCR
  • CRISPR edited genomes
  • Microbiome research/metagenomics

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Biochemical Assay Solutions Cancer Research

Our understanding of tumor biology is constantly evolving as well as new treatment strategies.  Although biochemical assays have been used for decades to detect and quantify biomolecules, they are an integral part of helping researches better understand tumor growth, angiogenesis, cancer progression, and metastasis. Whether your cancer research encompasses biomarker discovery, cell-signaling, GPCR research, or protein: protein interaction, our biochemical assay portfolio contains the tools you need to advance your cancer research and discovery.

For research purposes only. Not for use in diagnostic procedures.

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Cell-Based Solutions Cancer Research

Cell-based assays are a proven and powerful tool for gaining a more complete understanding of cancer biology, providing more meaningful results in more physiologically relevant systems than classical biochemical assays - instrumental in streamlining cancer research and drug discovery.

Whether you are a basic researcher trying to better understand biological processes in cancer cells or investigating how drugs affect those processes, we have the tools you need to advance your cancer research and discovery.

Our cell-based cancer research solutions allow you to:

  • Gain deeper insights from phenotypic screening of live cancer cells, 3D cell models, and stem cells with our high content screening and informatics solutions
  • Monitor the health of cells with luminescence assays
  • Study the mechanisms of metal-based chemotherapy resistance in single cells using our innovative SC-ICP-MS system
  • Compliment traditional histochemistry techniques using IR spectroscopy to evaluate features of the tumor microenvironment

For research purposes only. Not for use in diagnostic procedures.

Applications & Techniques

High-Content Analysis

Cell imaging has revolutionized cancer biology by enabling cells to be seen more clearly and in more detail.

Take your cell imaging to the next level with high-content analysis:

  • Gain more information from cellular samples and complex 3D cell models
  • Create meaningful functional screening assays for the development of drugs which prevent tumor growth and metastasis
  • Answer more questions simultaneously with multi-parametric data sets that are more information-rich compared to non-imaging read-outs

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Cytotoxicity & Cell Proliferation Assays

Cytotoxicity and cell proliferation assays are widely used in cancer research and drug discovery providing valuable insights to the health of cells.

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Single Cell ICP-MS for Cancer Research

Study the mechanisms of metal-based chemotherapy at the cellular level in individual cancer cells using Single Cell ICP-MS.

  • Gain a better understanding of how cancer cells become resistant to metal-based chemotherapy
  • Study and quantify uptake of metal-based nanoparticles in single cells for targeted cancer therapy
  • Evaluate effects of potentially new metal-based therapies

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Tumor Microenvironment

Identify chemical and morphologic features of the tumor microenvironment using Fourier transform infrared (FT-IR) spectroscopic imaging.

  • Innovative stain-free approach to compliment traditional histochemistry techniques
  • Differentiate molecular differences between normal and diseased tissues
  • Research transition of normal cells into cancerous cells in the tumor microenvironment

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Animal Imaging Solutions Cancer Research

Study cancer biology and assess therapeutic efficacy in vivo.

Small animal imaging is becoming an increasingly important tool for studying cancer research by providing investigators with unique capabilities to non-invasively detect and characterize cancer in vivo.

Whether you are monitoring tumor growth and progression, angiogenesis, metastases, performing drug efficacy and toxicology studies, or enhancing your understanding of cancer biology pathways, we have the tools to help with your next cancer discovery.

For research purposes only. Not for use in diagnostic procedures.

In vivo imaging workflow for cancer research

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Highlighted Applications

Cancer Immunotherapy & Immunology

Immuno-oncology has emerged as an exciting area of personalized medicine because of its tremendous potential to harness the powerful immune system to target and destroy cancer cells with few side effects, when targeted to the right tumor at the right time. Researchers are exploring the complex relationship between tumor cells and the immune system within the tumor microenvironment in order to discover new immuno-oncology targets and therapies.

Research Tools

Our cancer immunotherapy research solutions span the entire drug discovery workflow, from drug screening to studies in pre-clinical animal models to imaging of human tumor samples in clinical trials.

  • Immunoassays and reagents
  • Plate readers
  • Advanced multiplex tissue staining kits
  • Image analysis software
  • Quantitative pathology imaging systems
  • High content imaging and analysis
  • In Vivo imaging
  • Contract services

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Single Cell ICP-MS for Cancer Research

Metal-based chemotherapies such as Cisplatin are the most widely used class of drugs for the treatment of various cancers. Initially patients respond well to these drugs but often later relapse as the cancer displays resistance to the therapy. Metal-based chemotherapy works by forming crosslinks in DNA creating blockages which results in the cancer cells inability to replicate. Cellular uptake of metal-based drugs is related to tumor burden and consequently low intracellular levels of the drug are proportional to a decrease in tumor response.

Until now there has been little or no data about the distribution of the drug within individual tumor cells as traditional techniques can only measure the average concentration across the whole cell population. It’s clear that cells in the same population do not behave in the same way and the need to understand individual cell behavior is a trend across life science research in general. As a result, there is a growing need to analyze cellular uptake and distribution of metal-based or nanoparticle delivery of chemotherapy at the single cell level to determine if treatment is effective.

The innovative NexION® Single Cell ICP-MS system includes nebulizer technology allowing introduction of cells, one by one, as well as new software to calculate metal concentrations per cell. These will enable you to gain a better understanding of the mechanisms of how resistance develops in metal-based chemotherapies. With the NexION system you can rapidly detect and quantify metal concentrations in individual cancer cells to yield critical data about metal distribution in the cell population. This information may not only help you better understand chemotherapy resistance but can also lead to potential new therapies for cancer including in combination with other treatments such as immunotherapy.

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Contact us to see how we can help you with your next research breakthrough