PerkinElmer

Protein-protein Interaction Research

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Protein-protein interaction research is uncovering new targets for drug discovery in cancer and a variety of other diseases. However, measurement, modulation, and detection of protein-protein interaction is challenging, and requires technology capable of measuring both high- and low-affinity interactions.

The full measurement capabilities of our protein-protein interaction analysis technologies include:

  • Transient and stable interactions
  • Low-to-high affinity interactions (pM to mM affinity)
  • Full-length protein-protein binding
  • Peptide-protein
  • Receptor dimerization
  • Protein-small molecule
  • Protein complex interactions

Modulation of protein interactions can affect signal transduction, growth factor, gene expression, and other factors, making it a promising new avenue for protein-based treatment.

Development of protein-based therapeutics requires a thorough understanding of protein function and interactions. Our protein-protein interaction assays and instruments allow fast, multilabel detection of protein-protein interaction for drug discovery.

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Product Type
  • Accessories (3)
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  • Reagents (108)
Assay Target
  • 4-1BB (1)
  • 4-1BBL (1)
  • COX-2 (2)
  • EGF (2)
  • EGFR (3)
  • FCGR1 (1)
  • FCGR2A (2)
  • FCGR2B (1)
  • FCGR3A (2)
  • MMP-7 (1)
  • PD-1 (2)
  • PD-L1 (2)
Target Species
  • Human (10)
  • Mouse (1)
Application
  • Antibody binding (1)
  • Enzymatic (5)
  • Isotyping (1)
  • Multiplexing (2)
  • Protein Analysis & Detection (51)
  • Protein-nucleic acid interactions (4)
  • Protein-protein interactions (95)
Therapeutic Area
  • Biologics/Bioprocess (6)
  • Cancer (9)
Product Brand Name
  • Alpha (7)
  • AlphaLISA (40)
  • AlphaPlex (16)
  • AlphaScreen (12)
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  • LANCE (10)
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Detection Method
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  • Alpha (64)
  • DELFIA TRF (7)
  • Fluorescence (4)
  • Fluorescence Polarization (3)
  • Image-based Cytometry (1)
  • Luminescence (4)
  • Time-Resolved Fluorescence (TRF) (30)
  • TR-FRET (19)
Antibody Conjugates
  • Anti-6X His (7)
  • Anti-bovine IgA (1)
  • Anti-c-Myc (4)
  • Anti-C-tag (3)
  • Anti-DIG (2)
  • Anti-DNP (2)
  • Anti-FITC (3)
  • Anti-FLAG (6)
  • Anti-GFP (2)
  • Anti-goat IgG (1)
  • Anti-GST (5)
  • Anti-HA (4)
  • Anti-HRP (2)
  • Anti-human IgG (3)
  • Anti-MBP (1)
  • Anti-mouse IgG (3)
  • Anti-rabbit IgG (2)
  • Anti-rat IgG (2)
  • Anti-V5 (3)
  • Glutathione (3)
  • Nickel chelate (1)
  • Protein A (5)
  • Protein G (1)
  • Protein L (1)
  • Strep-Tactin (1)
  • Streptavidin (11)
  • Streptavidin/Anti-c-Myc (1)
  • Streptavidin/Anti-DIG (1)
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  • Unconjugated (2)
Radioisotope
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  • ULight (8)
Assay points(200-50,000)
  • 100 (5)
  • 10000 (11)
  • 500 (24)
  • 5000 (13)
  • 50000 (10)
Assay Target Class
  • Fc-receptor (6)
  • Protein (9)
Automation Compatible
  • Yes (111)
Experimental Type
  • In vitro (76)
Format
  • Microplates (82)
Maximum Temperature (Celsius)
  • 40-50 (2)
  • 50-60 (2)

"Protein-protein Interaction Research" 1-50 of 115 Products and Services

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EnVision 2105 multimode plate reader

EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

EnSight Multimode Plate Reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
ViewLux uHTS Microplate Imager

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is available outside the EU. Please contact your local representative to discuss alternative products.

VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
AlphaPlex Samarium Acceptor Beads

Protein A AlphaPlex™ 645 (Sm) Acceptor Beads

AlphaPlex-645 (Samarium) Acceptor beads conjugated to Protein A. These beads are used to capture immunoglobulins through their heavy chain (Fc region) allowing optimal orientation and antigen detection. Protein A has higher affinity for rabbit, pig, dog and cat IgG.
Price Range : 380.00 GBP - 15580.00 GBP

AlphaScreen Histidine (Nickel Chelate) Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and nickel chelate (Ni-NTA) AlphaScreen Acceptor beads. This kit contains enough reagents to run 500 wells in 384-well format, using a 25 µL reaction volume.
Price Range : 116.00 GBP - 8900.00 GBP
PerkinElmer

Protein A AlphaPlex™ 545 Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to Protein A, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP

AlphaScreen Mouse IgG Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-mouse IgG conjugated AlphaScreen Acceptor beads.
Price Range : 116.00 GBP - 8900.00 GBP

Anti-DNP AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.
Price Range : 514.00 GBP - 12000.00 GBP
PerkinElmer

SureLight Allophycocyanin-anti-FLAG antibody, 1 mg, lyophilized

APC-labeled anti-FLAG antibody, for capturing FLAG-tagged proteins and peptides in LANCE TR-FRET assays.
List Price : 351.00 GBP
Alpha donor antibody coated

Anti-HRP Alpha Donor Beads

Alpha Donor beads conjugated to anti-HRP antibody. These beads can be used to capture HRP-fusion proteins for Alpha no-wash detection, binding, and other assays.
Price Range : 302.00 GBP - 5450.00 GBP
AlphaPlex-545-antibody-bead2

Anti-human IgG AlphaPlex 545 Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-human IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP
Alphaplex-545-terbium-glutathione

Glutathione AlphaPlex™ 545 Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to glutathione, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP
Alpha donor antibody coated

Anti-DNP Alpha Donor Beads

Alpha Donor beads conjugated to anti-DNP antibody. These beads can be used to capture DNP-labeled proteins, peptides, and small molecules.
Price Range : 1030.00 GBP - 12000.00 GBP
PerkinElmer

SureLight Allophycocyanin-anti-6His antibody, 1 mg, lyophilized

APC-labeled anti-His antibody, for capturing His-tagged proteins and peptides in LANCE TR-FRET assays.
List Price : 351.00 GBP
AlphaPlex-545-unconjugated

Unconjugated AlphaPlex-545 Acceptor Beads

Unconjugated AlphaPlex 545 (Terbium) Acceptor beads bear reactive aldehyde groups at their surface, allowing you to conjugate a wide variety of reagents using a simple reductive amination protocol.
Price Range : 868.00 GBP - 18270.00 GBP

Anti-c-myc AlphaLISA® Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-c-myc antibody. These beads can be used to capture c-myc-tagged proteins and peptides in AlphaLISA no-wash assays.
Price Range : 380.00 GBP - 15590.00 GBP

ULight Anti-C-tag

ULight™ labeled anti-C-tag antibodies for LANCE® TR-FRET assays. This mouse monoclonal IgG1 antibody recognizes N-terminal and C-terminal Protein C tagged fusion proteins. The anti-C-tag antibody can be used to capture C-tag proteins, and can be used in conjunction with LANCE Europium-labeled reagents to create LANCE TR-FRET assays.
Price Range : 281.00 GBP - 6860.00 GBP
Alpha donor antibody coated

Anti-GFP Alpha Donor Beads

Alpha Donor beads conjugated to anti-GFP antibody. The antibody is a mouse monoclonal antibody that recognizes wildtype and recombinant GFP (rGFP), and cross-reacts with eGFP. These beads can be used to capture GFP-tagged proteins for AlphaScreen, AlphaLISA, and AlphaPlex no-wash assays.
Price Range : 395.00 GBP - 5670.00 GBP
Alpha donor antibody coated

Anti-DIG Alpha Donor beads

Alpha Donor beads conjugated to anti-DIG (digoxin) antibody. This bead can be used to capture Dig-labeled biomolecules for Alpha no-wash assays.
Price Range : 332.00 GBP - 5650.00 GBP

AlphaScreen General IgG (Protein A) Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Protein A conjugated AlphaScreen Acceptor beads.
Price Range : 58.00 GBP - 8900.00 GBP
PerkinElmer

LANCE Eu-W1024 Anti-6xHis

Europium-labeled anti-6X His antibody, for capturing His-tagged proteins in LANCE® TR-FRET assays.
Price Range : 145.00 GBP - 6870.00 GBP

Anti-FLAG AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-FLAG antibody. This mouse monoclonal M2 clone recognizes the FLAG sequence at the N-terminus, Met N-terminus, C-terminus, and internal sites.
Price Range : 380.00 GBP - 15590.00 GBP
DELFIA; Eu-N1 Rabbit Anti-Mouse-IgG

DELFIA® Eu-N1 Anti-HA

Europium-labeled anti-HA antibody for binding HA-tagged proteins in DELFIA® time-resolved fluorescence (TRF) assays. The anti-HA antibody is a purified IgG2b subclass of mouse monoclonal antibody. It recognizes the epitope sequence (YPYDVPDYA) derived from the human influenza hemagglutinin (HA) protein.
Price Range : 387.00 GBP - 3680.00 GBP

LANCE Eu-W8044 Streptavidin

Europium-labeled streptavidin, for capturing biotinylated biomolecules in LANCE TR-FRET assays. The W8044 chelate provides more stability than the W1024 chelate.
Price Range : 642.00 GBP - 5620.00 GBP

LANCE Ultra ULight™-anti-6xHis

Mouse monoclonal anti-polyHistidine tag antibody labeled with ULight™ dye.
Price Range : 277.00 GBP - 6870.00 GBP

Anti-GFP AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to anti-GFP antibody. The antibody is a mouse monoclonal antibody that recognizes wildtype and recombinant GFP (rGFP), and cross-reacts with eGFP. These beads can be used to capture GFP-tagged proteins for AlphaLISA no-wash assays.
Price Range : 380.00 GBP - 15590.00 GBP
AlphaPlex-545-antibody-bead2

Anti-Mouse IgG AlphaPlex-545 (Tb) Acceptor Beads

AlphaPlex-545 (Terbium) Acceptor beads conjugated to anti-mouse IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP

ULight anti-c-myc antibody

ULight labeled anti-c-myc antibody for LANCE® TR-FRET assays.
Price Range : 276.00 GBP - 6990.00 GBP
AlphaPlex-545-antibody-bead2

Anti-rabbit IgG AlphaPlex-545 (Tb) Acceptor Beads

AlphaPlex™-545 (Terbium) Acceptor beads conjugated to anti-rabbit IgG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP

Strep-Tactin® AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to Strep-Tactin®. These beads can be used to capture Strep-tag® II-tagged proteins for AlphaLISA no-wash assays.
Price Range : 369.00 GBP - 15150.00 GBP
DELFIA; Eu-N1 Rabbit Anti-Mouse-IgG

DELFIA® Eu-N1 Anti-c-myc

Europium-labeled anti-c-myc antibody, for capturing c-myc-tagged proteins in DELFIA® TRF assays.
Price Range : 413.00 GBP - 3680.00 GBP

AlphaScreen DIG (Digoxin/Digoxigenin) Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-Dig (digoxin) conjugated AlphaScreen Acceptor beads. 
Price Range : 116.00 GBP - 8900.00 GBP
AlphaLISA immunoassay kits

COX-2 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human COX-2 enables the detection and quantitation of human COX-2 in cell culture supernatants and cell extracts using a homogeneous AlphaLISA assay (no wash steps). The assay shows no cross-reactivity with human COX-1 nor with sheep COX-2.
Price Range : 2730.00 GBP - 20190.00 GBP
Alpha_Donor_bead_1

Alpha Glutathione Donor beads

Alpha Donor beads coated with glutathione.
Price Range : 325.00 GBP - 6080.00 GBP
Alphaplex_545_protein_coated

Streptavidin AlphaPlex™ 545 Acceptor Beads

Streptavidin-coated AlphaPlex™ 545 (Terbium) Acceptor beads, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP

Anti-rat IgG (Fc specific) AlphaLISA® Acceptor Beads

AlphaLISA® Acceptor beads conjugated to anti-rat IgG antibody. These beads can be used to capture rat IgG antibodies. The antibody is Fc-specific, and is a goat polyclonal F(ab')2 fragment.
Price Range : 380.00 GBP - 15590.00 GBP
PerkinElmer

LANCE Eu-W1024 Streptavidin

Europium-labeled streptavidin, for capturing biotinylated biomolecules in LANCE TR-FRET assays.
Price Range : 642.00 GBP - 5620.00 GBP
AlphaPlex-545-antibody-bead2

Anti-6X His AlphaPlex-545 (Tb) Acceptor beads

AlphaPlex-545 Acceptor beads conjugated to anti-6XHis antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP

Protein L AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to Protein L. These beads can be used to capture antibodies that bind Protein L for AlphaLISA no-wash assays.
Price Range : 380.00 GBP - 15590.00 GBP
PerkinElmer

LANCE Eu-W1024 Anti-c-Myc

Europium-labeled anti-c-myc antibody, for capturing c-myc-tagged proteins in LANCE® TR-FRET assays.
Price Range : 183.00 GBP - 8830.00 GBP

Streptavidin AlphaLISA® Acceptor beads

AlphaLISA® Acceptor beads conjugated to streptavidin. These beads can be used to capture biotinylated proteins, peptides, nucleic acids (DNA and RNA), and small molecules for AlphaLISA no-wash assays.
Price Range : 380.00 GBP - 15590.00 GBP
AlphaPlex Samarium Acceptor Beads

Anti-FLAG AlphaPlex-645 Acceptor Beads

AlphaPlex-645 (Samarium) Acceptor beads conjugated to anti-FLAG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP

MMP-7 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human MMP7 enables the detection and quantitation of human pro- and active MMP-7 (hMMP-7) in serum, buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 288.00 GBP - 6300.00 GBP

ULight-anti-V5 (LANCE TR-FRET)

Anti-V5 tag antibody labeled with ULight™ dye. This ULight-labeled reagent can be used to capture V5-tagged proteins and peptides, and can be used in conjunction with LANCE® Europium-labeled reagents to create TR-FRET no-wash assays for protein-protein interaction, protein detection, and enzymatic studies.
Price Range : 268.00 GBP - 6790.00 GBP
PerkinElmer

Eu-anti-V5 (LANCE TR-FRET)

Europium-labeled anti-V5 antibody, for capturing V5-tagged proteins in LANCE® TR-FRET assays. This Europium-labeled reagent can be used to capture V5-tagged proteins and peptides, and can be used in conjunction with LANCE® ULight or SureLight APC reagents to create TR-FRET no-wash assays for protein-protein interaction, protein detection, and enzymatic studies.
Price Range : 200.00 GBP - 5590.00 GBP
DELFIA; Eu-N1 Rabbit Anti-Mouse-IgG

DELFIA® Eu-N1 Anti-6xHis

Europium-labeled anti-6X His antibody, for capturing His-tagged proteins in DELFIA® TRF assays. The anti-6xHis antibody is a purified mouse IgG1 monoclonal antibody. It is raised against a polypeptide containing a 6x histidine tag. The antibody has been shown to detect polyhistidine tags localized at the amino- or carboxyl-terminus.
Price Range : 286.00 GBP - 2670.00 GBP

LANCE Ultra ULight™-anti-GST

Goat polyclonal anti-GST tag antibody labeled with ULight™ dye.
Price Range : 290.00 GBP - 6870.00 GBP
AlphaLISA binding assay principle

PD-1/PD-L1 (human) AlphaLISA Binding Kit

The AlphaLISA® PD-1/PD-L1 Binding Kit is designed for the detection of binding activity between Human PD-1 and PD-L1, using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of therapeutics which competitively inhibit PD-1/PD-L1 interaction.
Price Range : 449.00 GBP - 6300.00 GBP

AlphaScreen GST Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-GST conjugated AlphaScreen Acceptor beads. This kit contains enough reagents to run 500 wells in 384-well format, using a 25 µL reaction volume.
Price Range : 116.00 GBP - 8900.00 GBP

"Protein-protein Interaction Research" 1-50 of 115 Products and Services

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