PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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"Receptor Ligand Binding" 1-50 of 569 Products and Services

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MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

GBR 12935, [Propylene-2,3-3H]

GBR 12935, tritiated at the propylene-2,3 position. GBR 12935 is a piperazine derivative that acts as a selective dopamine reuptake inhbitor.
Price Range : 1710.00 GBP - 4830.00 GBP
PerkinElmer

Membrane Target Systems: GABA B1a in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1a receptor, 400 units.
List Price : 569.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 5, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 5 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 555.00 GBP

α-Dendrotoxin [125I]

NEX434 [125I]- α-Dendrotoxinsare a class of neurotoxins produced by mamba snakes that block particular subtypes of voltage-gated potassium channels in neurons. Dendrotoxins enhance the release of acetylcholine at neuromuscular junctions.
Price Range : 1070.00 GBP - 1700.00 GBP
PerkinElmer

Membrane Target Systems: Adenosine A3 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Adenosine A3 receptor, in HEK-293 cells.
List Price : 569.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 4, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 4 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 555.00 GBP

U-69,593, [Phenyl-3,4-3H]

U-69,593, tritiated at the phenyl-3,4 position. U-69,593 is a selective κ1-opioid receptor agonist.
Price Range : 553.00 GBP - 1800.00 GBP
Price Range : 958.00 GBP - 1840.00 GBP
Receptor-expressing cell lines

ValiScreen Somatostatin sst1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Urotensin UR2 (GPR14) (mouse) membrane preparation

Cell membranes prepared from cells stably-transfected with human Urotensin UR2 (GPR14) receptor, in CHO-K1 cells.
List Price : 569.00 GBP
PerkinElmer

CHO cell membranes, 10 mg

Wild Type Subtype CHO-K1 (chinese hamster) Control Membrane 10mg frozen suspension cell membrane. Shipped on dry ice.
List Price : 339.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 7, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 7 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 555.00 GBP
PerkinElmer

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 569.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 2, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 2 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 555.00 GBP
PerkinElmer

Membrane Target Systems: Serotonin 5HT7 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human serotonin 5HT7 receptor, 400 units.
List Price : 569.00 GBP

Raclopride, [Methoxy-3H]

Raclopride, tritiated on the methoxy group. Raclopride acts as a selective antagonist at dopamine D2 receptors. This product will have fresh lot dates on the second Monday in March and September in 2018.
Price Range : 446.00 GBP - 3570.00 GBP

Iodo-(±)-Cyanopindolol, [125I]

Iodo-(±)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.
Price Range : 1340.00 GBP - 2990.00 GBP

Rauwolscine, [Methyl-3H]-, 250µCi (9.25MBq)

Rauwolscine, tritiated on the methyl group. Rauwolscine acts as an antagonist at α2-adrenergic receptors.
List Price : 1500.00 GBP
PerkinElmer

Membrane Target Systems: Prostanoid CRTH2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP

Muscimol, 3-Hydroxy-5-Aminomethylisoxazole, [Methylene-3H(N)]

3H Muscimol radioligand. Muscimol acts as a potent selective agonist at GABAA receptors. It also acts as a partial agonist at GABAA-rho receptors.
Price Range : 1400.00 GBP - 3510.00 GBP

Insulin-like Growth Factor-I (human, recombinant), 125I

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.
Price Range : 685.00 GBP - 1680.00 GBP
PerkinElmer

PDE YSI 2G

SPA (scintillation proximity assay) beads designed for the capture of [3H]AMP or [3H]GMP on specially prepared yttrium silicate beads.
List Price : 2040.00 GBP
PerkinElmer

Membrane Target Systems: Neurotensin NTS1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP

Ryanodine, [9,21-3H(N)]-, 250µCi (9.25MBq)

Ryanodine, tritiated at the 9,21 position. Ryanodine is a natural ligand for the ryanodinen receptor.
List Price : 1840.00 GBP

PDGF [125I] (human)

NEX433 [125I]-PDGF BB homodimer has been shown to work in RIA and receptor studies, using CHO cell line transfected with human PDGF B receptor, and human artery smooth muscle cells.
Price Range : 949.00 GBP - 2140.00 GBP

Thyroxine, ([125I]-T4), 5700 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 916.00 GBP - 2690.00 GBP

Insulin (human, recombinant), [125I]

[125I]-Insulin (h) is suitable for the use in radioimmunoassay as well as receptor binding assay. [125I]-Insulin (h) is radioiodinated with no carrier added 125I using the LPO iodination procedure and is purified by reversed phase HPLC.
Price Range : 1100.00 GBP - 2140.00 GBP
PerkinElmer

Streptavidin PS Imaging Beads 500 MG

Streptavidin-coated SPA beads, for capturing biotinylated molecules in proximity-based scintillation assays.
List Price : 872.00 GBP

IP-10 (human, recombinant), [125I]-, Bolton-Hunter Labeled

Interferon gamma-induced protein 10 (IP-10; CXCL10), labeled with 125I. IP-10 binds the chemokine CXCR3 receptor, and is secreted in response to IFN-γ.
Price Range : 755.00 GBP - 1830.00 GBP
PerkinElmer

Membrane Target Systems: Vasoactive Intestinal Polypeptide VIP membrane preparation

Cell membranes prepared from HT29 cells containing human endogenous Vasoactive Intestinal Polypeptide (VIP) receptor.
List Price : 597.00 GBP
PerkinElmer

Membrane Target Systems: GABA B1b (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human GABA B1b receptor, 400 units.
List Price : 569.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 18, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 18 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 555.00 GBP

Vasopressin (Linear), V-1A Antagonist (Phenylacetyl1, 0-Me-D-Tyr2, [125I-Arg6]-)

Vasopressin (linear), labeled with 125I. Linear vasopressin acts as an antagonist at vasopressin receptor 1A (V1AR).
Price Range : 979.00 GBP - 2170.00 GBP

5-Hydroxytryptamine Binoxalate, [2-14C]

5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 2-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.
List Price : 2610.00 GBP

Somatostatin, [125I]Tyr11

Somatostatin, labeled with 125I. Somatostatin binds somatostatin receptors, and inhibits the secretion of insulin and glucagon.
Price Range : 918.00 GBP - 2140.00 GBP

Peptide YY (Human), ([125I]-PYY)

Peptide YY, labeled with 125I. Peptide YY acts as a neuropeptide Y receptor Y2 agonist, is released in response to feeding, and is associated with appetite saiety.
Price Range : 906.00 GBP - 2030.00 GBP

Iodoantipyrine, 4-[N-Methyl-14C]

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.
Price Range : 564.00 GBP - 4620.00 GBP
PerkinElmer

Membrane Target Systems: Orexin OX1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP

Nicotine, L-(-)-[N-Methyl-3H]

Nicotine radioligand tritiated on the methyl residue. Nicotine acts as an agonist at most nicotinic acetylcholine receptors; however it acts as an antagonist at two nicotinic receptor subunits (nAChRα9 and (nAChRα10). 
Price Range : 399.00 GBP - 3080.00 GBP

Bradykinin, [2,3-Prolyl-3,4-3H(N)]

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.
Price Range : 1410.00 GBP - 3210.00 GBP

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent

Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.
Price Range : 591.00 GBP - 1610.00 GBP

MDL105,519, [3H]

Tritiated MDL 105,519. MDL 105,519 acts as a potent and selective antagonist at N-methyl-D-aspartate (NMDA) receptors.
List Price : 2140.00 GBP

Norepinephrine, Levo-[ring-2,5,6-3H]

Levo-Norepinephrine, tritiated on the ring group. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
Price Range : 1060.00 GBP - 6760.00 GBP

"Receptor Ligand Binding" 1-50 of 569 Products and Services

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