PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Product Type
  • Consumables (2)
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Application
  • cAMP (26)
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  • White (4)
Coating Treatment
  • Anti-mouse antibody (2)
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Material
  • Barex/GF/B (1)
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  • Polystyrene/GF/B (1)
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Detection Method
  • Alpha (3)
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  • Radiometric (248)
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Receptor Type
  • 5-Hydroxytryptamine (12)
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  • Vesicular Amine Transporters (VATs) (1)
Assay Validated
  • Binding (209)
  • Calcium Fluorescence (21)
  • Calcium Luminescence (5)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (53)
  • Inositol Phosphate (15)
Sample Type
  • Enzyme (38)
Radioisotope
  • C-14 (6)
  • H-3 (109)
  • I-125 (77)
  • S-35 (1)
Radionuclide
  • 125I (77)
  • 14C (5)
  • 35S (1)
  • 3H (1)
  • 3H (108)
Fluorophore
  • Eu-N1-ITC (2)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (96)
  • Specifically Labeled (90)
  • Uniformly Labeled (1)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (179)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Automation Compatible
  • No (20)
  • Yes (44)
Concentration
  • 1 mCi/mL (3)
  • 1.0 - 10 mCi/mL (57)
  • 1.0 - 10 µCi/mL (3)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Experimental Type
  • In vitro (4)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (11)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (133)
  • HEK293 (38)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Length
  • 51-100 (6)
Number of Wells
  • 96 (4)
Pipetting Arms
Volume
  • 0-50 (44)
  • 51-100 (1)
  • 201-250 (56)

"Receptor Ligand Binding" 1-50 of 539 Products and Services

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MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
PerkinElmer

WGA-PEI TYPE A PS 50 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based scintillation assays.
List Price : 29.00 GBP
Alpha Bungarotoxin

Sauvagine, [125I]-Tyr0]

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.
Price Range : 1160.00 GBP - 2640.00 GBP
Diclofenac sodium- Phenylacetic acid C14

COUMARIN, 7-ETHOXY, [3- 14C]-

50 µCi quantities of 7-ETHOXY-[3-14C]-Coumarin are available for your research.
List Price : 1710.00 GBP
Alpha Bungarotoxin

Neurokinin B, [125I]His, MePhe7

Neurokinin B (NKB), labeled with 125I on the histidine residue. Neurokinin B is involved in ovarian cycle regulation, and binds neurokinin 3 receptor (NK3R; tachykinin receptor 3), a GPCR involved in vascular remodeling, angiogenesis, and cancer.
Price Range : 1090.00 GBP - 2550.00 GBP
PerkinElmer

Membrane Target Systems: Angiotensin AT2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 597.00 GBP
Adenosine 5 Triphosphate 250 µCi

SCH 23390, [N-Methyl-3H]

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.
Price Range : 458.00 GBP - 2500.00 GBP
Diclofenac sodium- Phenylacetic acid C14

Hydroxytryptamine Binoxalate (Serotonin Binoxalate), 5-[1-14C]

5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 1-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors. NEC855 replaces product NEC225, which was labeled at the 2-position.
Price Range : 671.00 GBP - 3260.00 GBP
PerkinElmer

WGA PS Imaging Beads 500 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based scintillation assays.
List Price : 289.00 GBP
Adenosine 5 Triphosphate 250 µCi

Citalopram, [N-Methyl-3H]

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).
Price Range : 974.00 GBP - 2130.00 GBP
Alpha Bungarotoxin

Thyroxine, ([125I]-T4), Specific Activity: 135-165 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 727.00 GBP - 2030.00 GBP
Alpha Bungarotoxin

MIP-1α (human, recombinant), [125I]

Human recombinant macrophage inflammatory protein 1-alpha (MIP-1α; CCL3), labeled with 125I. MIP-1α is a cytokine involved in acute inflammation, and binds C-C chemokine receptors CCR1, CCR4, and CCR5.
Price Range : 821.00 GBP - 3370.00 GBP
PerkinElmer

Membrane Target Systems: Adrenergic beta 3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 597.00 GBP
Adenosine 5 Triphosphate 250 µCi

8-Hydroxy-DPAT, [Propyl-2,3-ring-1,2,3-3H]-

8-OH-DPAT radioligand tritiated at the 1,2,3 position on the propyl-2,3-ring. 8-OH-DPAT is a serotonin receptor agonist specific for the 5-HT1A and 5-HT7 receptors.
Price Range : 1060.00 GBP - 2680.00 GBP
PerkinElmer

Membrane Target Systems: Neuromedin U NMU2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Neuromedin U NMU2 receptor, in HEK-293 cells.
List Price : 597.00 GBP
Alpha Bungarotoxin

Neurokinin A, ([125I]-Substance K

Neurokinin A (Substance K), labeled with 125I. Neurokinin A is a member of the tachykinin family of neuropeptide neurotransmitters, and is an endogenous agonist for NK-2 receptors. NK-2 receptors are potential drug targets for depression.
Price Range : 914.00 GBP - 2400.00 GBP
PerkinElmer

WGA PVT SPA 100 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.
List Price : 118.00 GBP
PerkinElmer

Membrane Target Systems: U-373 cell membranes

Wild Type Subtype U-373 (human) Control Membrane Frozen suspension cell membrane. Shipped on dry ice.
List Price : 356.00 GBP
PerkinElmer

Streptavidin PS 2G Imaging Beads

Streptavidin-coated SPA beads, for capturing biotinylated molecules in proximity-based scintillation assays.
List Price : 3830.00 GBP
Alpha Bungarotoxin

Iodo-(±)-Cyanopindolol, [125I]

Iodo-(±)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.
Price Range : 1470.00 GBP - 3730.00 GBP
Adenosine 5 Triphosphate 250 µCi

CGS 21680, [Carboxyethyl-3H(N)]

CGS 21680, tritiated at the carboxyethyl group. CGS 21680 acts as an agonist for the adenosine A2A receptor, but can also bind adenosine A1 and A3.
Price Range : 1610.00 GBP - 3880.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 20, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 20 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 582.00 GBP
Alpha Bungarotoxin

Glucagon, Receptor Grade, [125I]

Glucagon, labeled with 125I. This product is receptor grade, and was developed for use in receptor binding assays. Glucagon binds and activates glucagon receptor, a GPCR that is a potential drug target for diabetes, hyperplasia, and pancreatic disorders.
Price Range : 1150.00 GBP - 2430.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 2, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 2 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 582.00 GBP
Alpha Bungarotoxin

2`-Deoxycytidine-5`-triphosphate, 5-[125I] iodo-, Tetraammonium Salt

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
Price Range : 1230.00 GBP - 3060.00 GBP
Adenosine 5 Triphosphate 250 µCi

17α-HYDROXYPROGESTERONE, [1,2,6,7-3H]

17α-Hydroxyprogesterone (17α-OHP), tritiated at the 1,2,6,7 position. 17α-Hydroxyprogesterone is an agonist of the progesterone receptor (PR), an antagonist of the mineralocorticoid receptor (MR), and a partial agonist of the glucocorticoid receptor.
List Price : 1300.00 GBP
Adenosine 5 Triphosphate 250 µCi

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Price Range : 546.00 GBP - 4260.00 GBP
Receptor-expressing cell lines

ValiScreen Neuropeptide S NPS (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

Chloramphenicol, [Ring-3,5-3H]

Chloramphenicol, tritiated at the ring-3,5 position. Chloramphenicol is a broad spectrum antibiotic that binds to a receptor site on the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase.
Price Range : 1660.00 GBP - 4130.00 GBP
Alpha Bungarotoxin

Triiodothyronine, ([125I]-T3), Specific Activity: 1080-1320 µCi/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 879.00 GBP - 2540.00 GBP
Receptor-expressing cell lines

ValiScreen Opioid Kappa (OP2) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen TRH (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Adrenergic alpha 2A (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Streptavidin PS Imaging Beads 50 MG

Streptavidin-coated SPA beads, for capturing biotinylated molecules in proximity-based scintillation assays.
List Price : 98.00 GBP
Alpha Bungarotoxin

Ω-Conotoxin GVIA, [125I] Tyr22

Ω-Conotoxin GVIA (ω-Conotoxin GVIA), labeled with 125I on tyrosine residue 22. Omega conotoxin CVIA is a calcium channel blocker.
Price Range : 698.00 GBP - 2230.00 GBP
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 5, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
List Price : 1250.00 GBP
Adenosine 5 Triphosphate 250 µCi

Escitalopram, [N-methyl-3H]-

Escitalopram (Cipralex), tritiated at the N-methyl position. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (SERT) compared to the norepinephrine transporter (NET).
List Price : 3930.00 GBP
PerkinElmer

Membrane Target Systems: GABA B1a in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1a receptor, 400 units.
List Price : 597.00 GBP
PerkinElmer

Membrane Target Systems: Adenosine A3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 512.00 GBP
Alpha Bungarotoxin

ANGIOTENSIN II (human), [125I]-Tyr4 -50 μCi

Angiotensin II (human), labeled with 125I on the tyrosine (Tyr4) residue. Angiotensin II binds and activates angiotensin II receptor type 1 (AT1) and type 2 (AT2) receptors, a class of GPCRs important in vasoconstriction. Angiotensin II is a potential drug target for blood pressure regulation.
List Price : 2270.00 GBP
Receptor-expressing cell lines

ValiScreen Cholecystokinin CCK1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 25, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 25 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 582.00 GBP
PerkinElmer

Membrane Target Systems: GABA B1b in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1b receptor, 400 units.
List Price : 597.00 GBP
Alpha Bungarotoxin

Guanosine 3`,5`-cyclic Phosphoric Acid, 2`-O-succinyl Iodotyrosine Methyl Ester, [125I]

cGMP, labeled with 125I on the tyrosine methyl ester group. I-125 labeled cGMP can be used as a tracer for radioimmunoassays to detect levels of endogenous cGMP in a sample.
Price Range : 423.00 GBP - 6710.00 GBP

"Receptor Ligand Binding" 1-50 of 539 Products and Services

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