PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

  • Products and Services

  • Resources, Events & More

Narrow your results
Product Type
  • Consumables (2)
  • Instruments (7)
  • Reagents (536)
Application
  • cAMP (26)
  • Drug Discovery & Development (338)
  • Mobility Shift (36)
  • Plant Sciences (1)
  • Protein Analysis & Detection (5)
  • Protein-protein interactions (4)
  • Radiometric (4)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (180)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Assay Validated
  • Binding (210)
  • Calcium Fluorescence (21)
  • Calcium Luminescence (5)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (53)
  • Inositol Phosphate (15)
Automation Compatible
  • No (20)
  • Yes (44)
Coating Treatment
  • Anti-mouse antibody (2)
  • Anti-mouse IgG (2)
  • Anti-rabbit antibody (2)
  • Anti-rabbit IgG (2)
  • Copper (HIS-tag) (2)
  • Copper chelate (2)
  • Glutathione (4)
  • HIS (2)
  • Nickel chelate (HIS-tag) (2)
  • PDE (2)
  • PEI (14)
  • Poly-L-lysine (2)
  • Poly-lysine (5)
  • Protein A (2)
  • RNA Binding (1)
  • Streptavidin (13)
  • Uncoated (1)
  • WGA (17)
  • WGA PEI type A (1)
  • WGA PEI Type B (1)
Color
  • White (4)
Concentration
  • 1 mCi/mL (4)
  • 1.0 - 10 mCi/mL (60)
  • 1.0 - 10 µCi/mL (3)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Detection Method
  • Alpha (3)
  • DELFIA TRF (4)
  • Filtration (4)
  • Fluorescence (1)
  • Radiometric (253)
  • Time-Resolved Fluorescence (TRF) (4)
Experimental Type
  • In vitro (4)
Fluorophore
  • Eu-N1-ITC (2)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (11)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (134)
  • HEK293 (38)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (98)
  • Specifically Labeled (93)
  • Uniformly Labeled (1)
Material
  • Barex/GF/B (1)
  • Barex/GF/C (1)
  • Polystyrene/GF/B (1)
  • Polystyrene/GF/C (1)
Number of Wells
  • 96 (4)
Product Brand Name
  • AequoScreen (2)
  • AequoZen (3)
  • AlphaLISA (3)
  • cAMPZen (1)
  • DELFIA (4)
  • LabChip EZ Reader (50)
  • Membrane Target Systems (112)
  • MicroBeta (2)
  • NEN Radiochemicals (117)
  • NEN Radiolabeled Ligands (76)
  • OmniFilter (1)
  • SPA Imaging Beads (18)
  • SPA Scintillation Beads (26)
  • UniFilter (7)
  • ValiScreen (75)
Radionuclide
  • 125I (78)
  • 14C (5)
  • 35S (1)
  • 3H (1)
  • 3H (112)
Radioisotope
  • C-14 (6)
  • H-3 (113)
  • I-125 (78)
  • S-35 (1)
Receptor Type
  • 5-Hydroxytryptamine (12)
  • 5-Hydroxytryptamine (Serotonin) (23)
  • Acetylcholine (1)
  • Acetylcholine (Muscarinic) (16)
  • Adenosine (14)
  • Adrenergic (13)
  • Adrenoceptors (11)
  • Anaphylatoxin (4)
  • Angiotensin (9)
  • Apelin (2)
  • Benzodiazepine (6)
  • Bombesin (5)
  • Bradykinin (4)
  • Calcitonin (6)
  • Calcium (6)
  • Cannabinoid (8)
  • Chemokine (15)
  • Cholecystokinin (5)
  • Corticotropin-Releasing Factor (1)
  • Dopamine (20)
  • Dopamine Transporter (2)
  • Endothelin (3)
  • Epidermal Growth Factor (2)
  • Formyl Peptide (2)
  • Free Fatty Acid (2)
  • GABA (4)
  • GABAA (6)
  • GABAB (1)
  • Galanin (5)
  • Ghrelin (4)
  • Glucagon (6)
  • Glutamate (7)
  • Glycine (4)
  • Gonadotropin-releasing Hormone (1)
  • Growth Hormone (1)
  • hERG (3)
  • Histamine (9)
  • Insulin (3)
  • Insulin-like Growth Factor (1)
  • Interleukin (1)
  • Leukotriene (3)
  • Melanin-Concentrating Hormone (1)
  • Melanocortin (13)
  • Melatonin (2)
  • Metastin (1)
  • Motilin (1)
  • Muscarinic (10)
  • Neuromedin U (3)
  • Neuropeptide (7)
  • Neuropeptide Y (3)
  • Neurotensin (6)
  • Nicotinic (8)
  • NMDA (1)
  • Norephinephrine (1)
  • Norepinephrine (2)
  • Opioid (19)
  • Orexin (4)
  • Oxytocin (2)
  • Peptide P518 (1)
  • Platelet-Derived Growth Factor (1)
  • Potassium (2)
  • Progestin (1)
  • Prokineticin (1)
  • Prolactin Releasing Peptide (2)
  • Prostanoid (9)
  • Purinergic P2Y (2)
  • Relaxin (3)
  • Retinoic Acid Receptors (1)
  • Serotonin (4)
  • SK channels (1)
  • Somatostatin (11)
  • SVCT1 (1)
  • SVCT2 (1)
  • Tachykinin (7)
  • Thyroid Hormone (3)
  • Thyrotropin Releasing Hormone (1)
  • Thyrotropin-releasing Hormone (2)
  • Transforming Growth Factor (1)
  • TRPC5 (1)
  • Urotensin (2)
  • Vasoactive Intestinal Peptide (3)
  • Vasopressin (12)
  • Vesicular Amine Transporters (VATs) (1)
Sample Type
  • Enzyme (38)
Target Species
  • Human (10)
Therapeutic Area
  • Angiogenesis (27)
  • Biologics/Bioprocess (2)
  • Cancer (22)
  • Cardiovascular (119)
  • Central Nervous System (97)
  • CNS & Neurologic (125)
  • Diabetes (20)
  • Gastrointestinal (76)
  • Immune (3)
  • Inflammation (138)
  • Metabolic (52)
  • Metabolic Disorders (42)
  • Musculoskeletal (1)
  • Obesity (9)
  • Pain (72)
  • Parasympathetic Nervous System (5)
  • Renal (2)
  • Sympathetic Nervous System (2)
Volume
  • 0-50 (45)
  • 51-100 (1)
  • 201-250 (59)

"Receptor Ligand Binding" 1-50 of 545 Products and Services

Sort
Per Page

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

Ω-Conotoxin MVIIC, [125I]

Ω-Conotoxin MVIIC (ω-Conotoxin MVIIC), labeled with 125I. Ω-Conotoxin MVIIC is a neurotoxin that blocks calcium channels.
Price Range : 754.00 GBP - 1980.00 GBP

Guanosine 3`,5`-cyclic Phosphoric Acid, 2`-O-succinyl Iodotyrosine Methyl Ester, [125I]

cGMP, labeled with 125I on the tyrosine methyl ester group. I-125 labeled cGMP can be used as a tracer for radioimmunoassays to detect levels of endogenous cGMP in a sample.
Price Range : 385.00 GBP - 6100.00 GBP
PerkinElmer

Membrane Target Systems: Serotonin 5HT5a (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Serotonin 5-HT5a receptor, in HEK-293 cells.
List Price : 569.00 GBP

Human IgG-conjugated AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to human IgG (whole). These beads are intended for use in homogenous Alpha assays to capture Fc receptors.
Price Range : 499.00 GBP - 15190.00 GBP
Receptor-expressing cell lines

ValiScreen Leukotriene BLT1 (LTB4R1) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

ROLIPRAM, [METHYL-3H]

Rolipram, tritiated on the methyl group. Rolipram is a selective phosphodiesterase-4 inhibitor.
List Price : 2770.00 GBP
Adenosine 5 Triphosphate 250 µCi

Citalopram, [N-Methyl-3H]

Citalopram, tritiated at the N-methyl group. Citalopram is a selective serotonin reuptake inhibitor (SSRI) antidpressant drug, and has been shown to block the serotonin transporter (SERT, 5-HTT).
Price Range : 886.00 GBP - 1930.00 GBP
Adenosine 5 Triphosphate 250 µCi

Dihydroxyphenylethylamine, 3,4-[7-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors. This product has a scheduled lot release for the second Monday in April and October.
Price Range : 641.00 GBP - 1800.00 GBP
PerkinElmer

Membrane Target Systems: Dopamine D1 (human) membrane preparation, in L cells cells. 400 Units.

Cell membranes prepared from L cells stably-transfected with human dopamine D1 receptor, 400 units.
List Price : 569.00 GBP
PerkinElmer

Streptavidin PS Imaging Beads 500 MG

Streptavidin-coated SPA beads, for capturing biotinylated molecules in proximity-based scintillation assays.
List Price : 872.00 GBP
Receptor-expressing cell lines

ValiScreen Adenosine A2a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

Dopamine Transporter (human) Cell Line

Our stable recombinant cell lines express a variety of receptors for binding and functional assays.
List Price : 10930.00 GBP

Triiodothyronine, ([125I]-T3), Specific Activity: 3300 µCi/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 755.00 GBP - 2550.00 GBP
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-2C (ne) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: TRH (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP

Ω-Conotoxin GVIA, [125I] Tyr22

Ω-Conotoxin GVIA (ω-Conotoxin GVIA), labeled with 125I on tyrosine residue 22. Omega conotoxin CVIA is a calcium channel blocker.
Price Range : 634.00 GBP - 2030.00 GBP

TGF-β1 (human, recombinant), [125I]

Transforming growth factor beta 1 (TGF-β1), labeled with 125I. TGF-β1 is a cytokine that is involved in cell growth, cell differentiation, and apoptosis.
Price Range : 858.00 GBP - 2150.00 GBP

N-succinimidyl-3-(4-hydroxy-3-[125I]iodophenyl)propionate, Bolton-Hunter Reagent

Bolton-Hunter reagent, monoiodinated. This product is used to iodinate proteins that do not contain tyrosine residues. Bolton-Hunter reagent is the N-hydroxysuccinimide ester of iodinated p-hydroxyphenylpropionic acid. The active ester acylates terminal amino groups with the iodinated p-hydxyphenylpropionic residue, effectively introducing radioactive iodine into proteins and peptides. A non-oxidative technique, it is less harsh to proteins than alternative labeling methods. An anhydrous benzene A charcoal trap is provided with each vial.
Price Range : 591.00 GBP - 1610.00 GBP
Adenosine 5 Triphosphate 250 µCi

5-CT, [3H]

5-carboxyamidotryptamine (5-CT) labeled with tritium. 5-CT is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 serotonin receptors. It also binds the 5-HT2, 5-HT3, 5-HT6 serotonin receptors with lower affinity.
List Price : 1010.00 GBP
PerkinElmer

Membrane Target Systems: Galanin Gal1 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human galanin Gal1 receptor, 400 units.
List Price : 553.00 GBP
Adenosine 5 Triphosphate 250 µCi

Bradykinin, [2,3-Prolyl-3,4-3H(N)]

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.
Price Range : 1410.00 GBP - 3210.00 GBP
PerkinElmer

Streptavidin PVT 2G

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.
List Price : 6680.00 GBP
PerkinElmer

Membrane Target Systems: A9 cells membranes

Wild Type Subtype A9L (mouse) Control Membrane 10mg Frozen suspension cell membrane. Shipped on dry ice.
List Price : 339.00 GBP
Receptor-expressing cell lines

ValiScreen Bombesin BB2 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Serotonin 5HT-2B (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP
Adenosine 5 Triphosphate 250 µCi

Cytisine HCl, [3,5-3H(N)]

Cytisine HCl, [3,5-3H(N)]- will have fresh lot dates on the second Monday in April.
Price Range : 476.00 GBP - 1710.00 GBP
PerkinElmer

Membrane Target Systems: Serotonin 5HT-6 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP
Adenosine 5 Triphosphate 250 µCi

Vinblastine Sulphate, [G-3H]

Vinblastine sulphate, tritiated. Vinblastine binds to tubulin and inhibits microtubule formation.
Price Range : 1220.00 GBP - 4570.00 GBP
PerkinElmer

Membrane Target Systems: Glutamate mGlu5a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP
PerkinElmer

HIS-Tag Beads YOX 500 MG

SPA beads for capturing His-tagged proteins and peptides.
List Price : 1390.00 GBP
Adenosine 5 Triphosphate 250 µCi

Oxotremorine-M Acetate, [Methyl-3H]-,>97%, 250µCi (9.25MBq)

Oxotremorine-M acetate, tritiated on the methyl group. Oxotremorine-M acts as a selective agonist at muscarinic acetylcholine receptors.
List Price : 1830.00 GBP

Neurokinin B, [125I]His, MePhe7

Neurokinin B (NKB), labeled with 125I on the histidine residue. Neurokinin B is involved in ovarian cycle regulation, and binds neurokinin 3 receptor (NK3R; tachykinin receptor 3), a GPCR involved in vascular remodeling, angiogenesis, and cancer.
Price Range : 995.00 GBP - 2320.00 GBP

Gastric Inhibitory Polypeptide (human), [125I]

Gastric inhibitor polypeptide (GIP), labeled with 125I. GIP is a hormone that binds receptors found on beta cells in the pancreas.
Price Range : 958.00 GBP - 1840.00 GBP
Adenosine 5 Triphosphate 250 µCi

SR 95531, [Butyryl-2,3-3H]-, 250µCi (9.25MBq)

SR-95531 (Gabazine), tritiated at the butyryl-2,3 position. SR-95531 acts as an antagonist at GABAA receptors.
List Price : 1840.00 GBP
PerkinElmer

Membrane Target Systems: GABA B1b in HEK (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably transfected with human GABA B1b receptor, 400 units.
List Price : 569.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 18, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 18 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 555.00 GBP
PerkinElmer

Membrane Target Systems: Serotonin 5HT7 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human serotonin 5HT7 receptor, 400 units.
List Price : 569.00 GBP
Adenosine 5 Triphosphate 250 µCi

Histamine Dihydrochloride, [Ring, Methylenes-3H(N)]

Histamine dihydrochloride, tritiated on the ring and methylene groups. Histamine is an endogenous agonist of histamine receptors.
Price Range : 864.00 GBP - 1880.00 GBP
Adenosine 5 Triphosphate 250 µCi

Diltiazem, cis-(+)-[N-Methyl-3H]

cis-(+)-Diltiazem, tritiated at the N-methyl position. Diltiazem is a non-DHP calcium channel blocker.
Price Range : 1310.00 GBP - 2940.00 GBP

UniFilter-96 GF/C PEI Coated Plates

PEI-coated GF/C glassfibre filter-bottom 96-well microplate, for receptor binding and cell harvesting assays using a vacuum manifold.
List Price : 589.00 GBP
Adenosine 5 Triphosphate 250 µCi

Prazosin, [7-Methoxy-3H]

Prazosin, tritiated at the 7-methoxy position. Prazosin acts as an inverse agonist at the α1-adrenergic receptor.
Price Range : 558.00 GBP - 4410.00 GBP
PerkinElmer

Membrane Target Systems: Gastric Inhibitory Polypeptide GIP (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Gastric Inhibitory Polypeptide (GIP) receptor, in HEK-293 cells.
List Price : 569.00 GBP
PerkinElmer

Membrane Target Systems: Bombesin BB2 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP

"Receptor Ligand Binding" 1-50 of 545 Products and Services

Per Page