Fluorescencein situ hybridization (FISH) is a powerful technique for detecting RNA or DNA sequences in cells, tissues and tumors. FISH provides a unique link among the studies of cell biology, cytogenetics and molecular genetics. It uses fluorescent probes that only bind to the parts of the chromosome with which they show a high degree of sequence similarity.
Fluorescence microscopy can be used to identify FISH signals in nuclei as fluorescent spots and can distinguish different samples bound to the chromosomes using different colored fluorescent probes.
Solutions for Fluorescence in situ hybridization
Drawing on many years of experience and in-depth knowledge, PerkinElmer offers solutions for every throughput, a starting point for typical FISH applications and unlimited possibilities for customization.
FISH spots identified in the nuclei of cells. The different colors represent spots belonging to individual nuclei