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Dihydroxyphenylethylamine (Dopamine), 3,4-[Ring-2,5,6-3H]-, 250µCi (9.25MBq)

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the ring-2,5,6- position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.

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Part Number Unit Size List Price Your Price Quantity
NET673250UC 250 µCi 512.00 GBP
NET673001MC 1 mCi 1190.00 GBP
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Dihydroxyphenylethylamine binds dopamine receptors, a class of GPCRs in the central nervous system. Dopamine receptors are implicated in motivation, pleasure, cognition, memory, and learning and are potential drug targets for schizophrenia, Parkinson's disease, and a variety of other psychiatric and neurological conditions.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET673:

  1. Schmitt, M., Dehay, B., Bezard, E. and Garcia-Ladona, F. J. (2016), Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line. Synapse, 70: 71–86.
  2. A.L. Auclair, J.C. Martel, M.B. Assié, L. Bardin, P. Heusler, D. Cussac, M. Marien, A. Newman-Tancredi, J.A. O'Connor, R. Depoortère, Levomilnacipran (F2695), a norepinephrine-preferring SNRI: Profile in vitro and in models of depression and anxiety, In Neuropharmacology, Volume 70, 2013, Pages 338-347.


Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 153.0
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Dopamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi