PerkinElmer
check quantity

Diprenorphine [15,16-3H]-, 25µCi (925kBq)

Diprenorphine (Revivon; M5050; diprenorfin), tritiated at the 15,16- position. Diprenorphine acts as a non-selective antagonist at opioid receptors.

You successfully added item(s) to your cart

Part Number
Unit Size
List Price
Your Price
Quantity
NET1121025UC
25 µCi
476.00 GBP
more
NET1121250UC
250 µCi
991.00 GBP
more
Buy Now

Please enter valid quantity

Please login to add favorites

NULL OR EMPTY CART

Detail Information

Diprenorphine acts as an antagonist at the μ-opioid receptor (MOR), κ-opioid (KOR), and δ-opioid receptor (DOR) and is used to reverse the effects of potent opioid analgesics in veterinary medicine. The opioid receptors are a group of GPCRs that are potential drug targets for pain, depression, and drug abuse.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1121:

  1. Floettmann E, Bui K, Sostek M, Payza K, Eldon M. (2017), Pharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation. J Pharmacol Exp Ther, 361(2): 280-291.
  2. Marino, S. F. (2009), High-level production and characterization of a G-protein coupled receptor signaling complex. FEBS Journal, 276: 4515–4528.

Specifications

Detection Method Radiometric
Label Position Specifically Labeled
Molecular Weight 425.6
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type Opioid
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain, Inflammation
Unit Size 25 µCi
Resources, Events & More
  • All

Brochure

Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

PDF 2 MB