PerkinElmer
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IVIS Lumina III In Vivo Imaging System

The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.

Part Number CLS136334
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For research use only. Not for use in diagnostic procedures.

Detail Information

The IVIS Lumina III is capable of imaging both fluorescent and bioluminescent reporters. The system is equipped with up to 26 filter sets that can be used to image reporters that emit from green to near-infrared. Superior spectral unmixing can be achieved by Lumina III’s optional high resolution short cut off filters.

Features and Benefits

  • Market trusted technology offering the fullest suite of leading imaging technologies, reagents and support
  • Exquisite sensitivity in bioluminescence
  • Full fluorescence tunability through the NIR spectrum
  • Compute Pure Spectrum spectral umixing for ultimate fluorescence sensitivity
  • Expandable system tailored to your workflow

Specifications

Height 104.0 cm
Imaging Modality Optical Imaging
Length 71.0 cm
Optical Imaging Classification Bioluminescence imaging, Fluorescence Imaging
Portable No
Product Brand Name IVIS
Width 48.0 cm
Resources, Events & More
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Application Note

Cerenkov Imaging of Radioisotopes in IVIS systems

Cerenkov Emission from radioisotopes in tissue,Optical imaging detects photons in the visible range of the electromagnetic,spectrum. PET and SPECT imaging instruments are sensitive to photons in the much,higher energy range of x-rays and gamma rays. While the PET and SPECT probes,which can generate Cerenkov light in tissue will continue to produce the relevant,gamma- and x-rays, visible photons will be produced from the Cerenkov emission,which the IVIS® will detect.,In beta decay emitters such as PET probes and isotopes such as 90Y, 177Lu, 131I and 32P,the beta particle will travel in the tissue until it either annihilates with an electron or,loses momentum due to viscous electromagnetic forces.,It is possible that the beta (electron or positron),is relativistic, traveling faster than the speed,of light in the tissue. While it is impossible,to travel than the speed of light in a vacuum,(c), the speed of light in tissue is v = c / n,where n is the tissue index of refraction and,n = 1. Cerenkov photons will be generated,by a relativistic charged particle in a dielectric medium such as tissue.

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IVIS Lumina Series III Bioimaging of Gene Delivery with In Vivo-jetPEI Application Note

Pre-clinical in vivo imaging application note on Bioimaging of Gene Delivery with In Vivo-jetPEI®. The delivery of nucleic acids into cells is essential for basic research as well as medical applications such as gene therapy. Viral vectors are efficient carriers, but their use is limited because of their safety (induction of immune response, virus-associated pathogenicity). These concerns have increased the interest of non-viral methods for in vivo gene delivery. Second generation of non-viral vectors offers improved performance and safety, potentially providing an alternative to viral gene delivery.

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Stem Cell Research and Regenerative Medicine

With the potential to treat a wide range,of disease, from organ damage to,congenital defects, stem cell research,and tissue engineering form the underlying,basis of regenerative medicine. Significant,advances in the science of skin regeneration,for example, have now made it possible to,develop and grow artificial skin grafts in a,lab for treatment of burn victims. Other therapeutic applications include the use of,stem cells to treat and repair central nervous system diseases such as ischemia and,cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including,type I diabetes. However, critical research addressing safety concerns, exploring,therapeutic function, and assessing mechanisms of action must be completed prior,to human adoption. IVIS® technology is being widely used to explore stem cell,research outcomes in preclinical small animal models, which serve as key test pre-cursors to human clinical trials.

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Product Note

IVIS Lumina Series III Product Note

IVIS Lumina Series III Integrating Gold Standard Bioluminescence and Fluorescence In Vivo Technologies. The IVIS Lumina Series III from PerkinElmer provides an expandable, sensitive imaging system that is easy to use for both fluorescent and bioluminescent imaging in vivo. The Lumina Series III platform offers a full spectrum of wavelengths to perform almost any in vivo optical application with a tunability of 20 nm. The system includes a highly sensitive CCD camera, light-tight imaging chamber and complete automation and analysis capabilities. As the leading optical imaging platform for in vivo analysis, IVIS systems include a range of practical accessories developed through experience in research laboratories worldwide.

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RAS-4 Rodent Anesthesia System

The Xenogen XGI-8 Gas Anesthesia System is designed to work with the IVIS Imaging System, a technology from Xenogen that allows researchers to use r eal-time in vivo imaging to monitor and record cellular and genetic activity within a living organism.

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Software Downloads

Technical Note

Adaptive Fluorescence Background Subtraction

Adaptive Fluorescence Background Subtraction Pre-clinical in vivo imaging technical note for IVIS Imaging Systems. Instrument background occurs when excitation light leaks through the emission filter. This occurs more frequently when the excitation and emission filters are narrowly separated. The ring you see is a result of non specific light reflecting off of the stage at an incident angle and passing through the filter causing what appears as leakage around the edges.

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AutoExposure

Auto-exposure technical note for IVIS pre-clinical imaging systems

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Background ROI

Subtracting Background ROI from a Sequence

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Determine Saturation

Determine Saturation for IVIS imaging systems - technical note

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Drawing ROIs

Technical notes for Drawing ROIs for IVIS in vivo imaging systems. The circle, square, free draw, or grid (for well plates) can be used to draw your ROIs. ROI selections,are user-specific and are dependent on the model being analyzed. It is irrelevant which shape that is used for a particular ROI.

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Image Overlay 2D

Not only is it possible to load multiple images as a group, for example multiple days of a longitudinal study, but it is also possible to load multiple images and Overlay them i.e. bioluminescent tumor with fluorescent targeted drug acquired in two separate images.

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Kinetic Analysis of Bioluminescent Sources

Acquiring the most accurate quantitation of your bioluminescent sources requires a close understanding of the underlying kinetics involved in producing and capturing the detected light. After injection, the substrate for your bioluminescent probe will di

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Loading Groups of Images

For many studies, it may be desirable to open a group of images together, for example, analyzing multiple days of longitudinal study side by side using the same scale.

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Subject ROI

Subject ROI using IVIS imaging systems

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Working with Image Math

Working with Image Math. Image Math is a rudimentary but effective method for Spectrum and Lumina users to subtract background from images without performing Spectral Unmixing.

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Video Article