PerkinElmer
  • Research Areas

Applied Genomics

PerkinElmer’s optimized, automated solutions are designed to improve the efficiency of your genomic workflows. These solutions are designed to eliminate the challenges associated with genomic analysis by providing labs with complete, single source solutions encompassing everything from sample to solution.

Automated workflow solutions have been developed for a range of applications including nucleic acid isolation and PCR setup, NGS sample prep, long-read sequencing, CRISPR fragment analysis, molecular cytogenetics and protein characterization. By enabling complete application-based solutions PerkinElmer increases your throughput while simplifying the generation of accurate, reproducible analysis. These solutions offer the flexibility to automate of automating a single protocol within your workflow or obtaining a complete single source solution that has been optimized to meet specific application requirements.

Explore the areas below to learn how you can increase the efficiency of your applications.

For research use only. Not for use in diagnostic procedures.

Applications

Nucleic Acid Isolation and PCR Setup

We offer automated solutions for nucleic acid isolation and PCR setup to increase the throughput and reproducibility of PCR workflows for virtually any application. Our automated solutions for nucleic acid isolation, analysis, purification of PCR products, and PCR setup are designed to increase the efficiency of endpoint, real-time, RT, and multiplex PCR experiments.

PerkinElmer offers several different solutions for automated nucleic acid isolation based on your sample volume and throughput needs. These solutions are grounded in the proprietary chemagen bead-based nucleic acid isolation technology, delivering high-yield and purity DNA and RNA for PCR analysis. Additionally, we offer solutions for PCR product purification PCR products, which removing impurities that maintain PCR yield.

PerkinElmer offers automated microfluidic devices simplifying the analysis of input concentration and qualitative assessment of PCR products replacing the multiple, manual steps of slab gel electrophoresis with high levels of accuracy and throughput.

With liquid handlers ranging in size from benchtop to large integrated workstations, PerkinElmer offers PCR setup automation solutions to meet any of your throughput needs.

Explore the areas below to learn how you can increase the efficiency of your PCR experiments.

For research use only. Not for use in diagnostic procedures.

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Protein Characterization

Sample preparation and characterization of proteins for quality by design (QbD) studies are important parts of process development; however, these studies, including design of experiments(DoE), can be time consuming and sample analysis can easily exceed the capacity of most labs.

Protein characterization involves both upstream protein purification optimization, as well as the downstream characterization of its purity, structure and function. Miniaturization of small-scale protein purification provides greater process optimization with larger QbD and DOE studies allowing for parallel processing of samples for increased statistical significance and greater breadth of variables within experimental shorter time frames.

PerkinElmer is committed to accelerating this process to help life science researchers make critical decisions earlier in the protein development workflow. Researchers can now screen for optimal protein characteristics earlier in the process, integrating Quality by Design initiatives into their protein therapeutic development workflow.

For research use only. Not for use in diagnostic procedures.

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AG NGS Workflow Solutions

With our optimized nucleic acid extraction, DNA/RNA quantitation, automated library preparation, NGS library QC prep kits and technical expertise, you have an ally who understands your underlying science and can provide the solutions that address the full breadth of your scientific requirements-all from a single-source who delivers the application support you need to be productive right from the start.

Applications Support - From Extraction to Analysis

  • Nucleic acid isolation
  • Whole genome sequencing
  • Exome sequencing
  • Targeted amplicon sequencing
  • Transcriptomics
  • Epigenomics
  • cfDNA research
  • PCR/qPCR
  • Genotyping
  • CRISPR edited genomes
  • Microbiome research/metagenomics
  • Plant genomics

For research use only. Not for use in diagnostic procedures

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Long-Read Sequencing

The predominant method for large-scale population research analysis of whole-genomes has historically involved sequencing an individual genome using short-reads, and aligning to a consensus reference sequence. Shortcomings of this method include loss of haplotype knowledge, genetic phasing information, and structural variation. While short-read sequencing provides sufficient power to call single nucleotide variants (SNVs) across most of the consensus genome, a comprehensive analysis of the genome of each unique individual is not possible.

The 10x Genomics® Chromium Genome Solution uses the power of Linked-Reads, a unique data type, to tag short reads from the same high molecular weight genomic DNA fragment with molecular barcodes, thus allowing the placement of short-read information in the context of the whole genome. This unique approach resolves genetic phasing and structural variation, and detects variants in previously inaccessible and complex regions of the genome.

PerkinElmer and 10x Genomics have created an efficient, automated workflow to maximize high molecular weight gDNA extraction, sample QC, and sample prep, providing Linked-Reads sequencing capabilities for a variety of sample types including saliva, dried blood spots, blood, and plasma.

For research use only. Not for use in diagnostic procedures.

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CRISPR

Streamline Your Analysis of CRISPR-Cas9 Genome Editing

CRISPR-Cas9 genome editing is a transformative technology that allows researchers to edit sections of DNA with a high degree of precision. The CRISPR system can be exploited by researchers to target specific genetic loci, enabling them to edit DNA at precise locations, permanently modifying cells and organisms. This genome editing can be used to create animal models and cell models of diseases of interest, facilitating new avenues of research.

The LabChip® GX Touch Electrophoresis System is an invaluable tool to simplify and accelerate CRISPR-Cas9 experiments and analysis. The LabChip GX Touch Electrophoresis System:

  • Assesses DNA fragments at concentrations as low as 2 pg/µL
  • Analyzes up to 384 samples in as little as 28 seconds per sample
  • Identifies slight differences in sample size with high degrees of sensitivity and resolution
  • Improves reproducibility and precision of analysis
  • Cited in over 100 CRISPR studies

For research use only. Not for use in diagnostic procedures.

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Microfluidic Protein Characterization Analysis

Microfluidic Electrophoresis Analysis

Proteins differ from each other in their size, molecular structure and physiochemical properties. These differences allow for protein analysis and characterization by separation and identification. The LabChip® GXII Touch protein characterization system offers rapid peak quantification and quality control throughout the protein purification workflow.

The platform supports multiple assays for characterizing proteins in reduced and non-reduced samples including:

  • Analyze critical quality attributes in as few as 42 seconds:
  • Titer (concentration and sizing)
  • Purity assessment
  • Aggregation (covalently linked)
  • Stability (degradation / fragmentation analysis)
  • N-Glycan profiling
  • mAb Charge variant / charge heterogeneity
  • mAb impurity analysis (detect minor impurities)

Analysis can be performed in as few as forty seconds per sample that deliver comparable data to traditional capillary electrophoresis with as much as a 70X increase in throughput. Choose 96-well or up to 384-well platforms depending upon throughput needs. With an easy to use touch screen interface, even occasional users get up and running samples quickly.

For research use only. Not for use in diagnostic procedures.

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Solutions

Integrated Laboratory Automation

From cellular screening and imaging applications to high-throughput screening and genomics-based applications, custom explorer G3 integrated workstations provide innovative application-focused laboratory automation solutions which simplify microplate handling, liquid handling, and detection. With complete high-throughput multimode plate detection, high content analysis, and liquid handling portfolios, PerkinElmer is uniquely positioned to understand your scientific and application needs. You can count on us to provide solutions that address the full breadth of your scientific requirements, all from a single source who delivers the application support you need. Additionally, a variety of instrumentation from other suppliers can be integrated into an explorer G3 integrated workstation.

Multiple robotic arm options enable integrations that immediately accelerate both routine and complex workflows. In combination with our plate::works automation and scheduling software, the explorer G3 integrated workstations enable you to take full control of the automation process, through intuitive interface guides and scheduling software.

For research use only. Not for use in diagnostic procedures.

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Nucleic Acid Isolation - Research

Based on PerkinElmer patented magnetic bead technology the chemagic instruments represent ideal solutions for nucleic acid isolation in a huge variety of research market segments including but not limited to Human Genetics, Biobanking, HLA Typing, Virus and Bacteria Detection.

Benefit from flexible solutions tailored to your sample processing and throughput needs.

For Research Use Only. Not for use in diagnostic procedures.

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Automation & Liquid Handling Instruments

With dedicated workstations designed for a diverse variety of applications, along with the ability to customize liquid handling workstations based on your needs, our innovative automated liquid handling solutions enable you to minimize errors, reduce hands-on time, and increase throughput and reproducibility. With flexibility in throughput, capacity and dynamic volume range, high quality manufacturing standards, and outstanding customer service and support, we offer solutions optimized to meet your laboratory’s needs.

From benchtop application-specific workstations to complex customized integrated solutions our liquid handing portfolio automates your science.

For research use only. Not for use in diagnostic procedures.

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NGS Library Prep Kits

NEXTflex® library preparation kits are designed to reduce bias and increase the sensitivity, flexibility, and speed of library prep for both Illumina® and Ion Torrent sequencing platforms. An extensive selection of NEXTflex single index and dual index barcoded adapters is available to meet your specific multiplexing needs. Automation protocols for the PerkinElmer® Sciclone® NGS Workstation are available for many of the NEXTflex library prep kits for labs requiring higher sample throughput, reduced hands-on time, greater reproducibility, or improved process control.

For research use only. Not for use with diagnostic procedures.

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Nucleic Acid Analysis and Protein Characterization

Utilizing automated microfluidic capillary electrophoresis (micro-CE) technology, our instruments enable the user to simplify the process of traditional gel separations, resulting in even more accurate and reproducible data in a fraction of the time. Separate, identify and analyze genomic and protein samples in seconds and visualize your data as an electropherogram, virtual gel, or tabular report.
  • The LabChip® GX Touch nucleic acid analyzer performs DNA/RNA separation and analysis with minimal concentration requirements. This platform is ideal for NGS applications including cfDNA, FFPE, and PCR-free DNA quantitation.
  • The LabChip® GXII Touch protein characterization system makes protein quantitation fast with capillary electrophoretic separation. Detect, quantitate, and assess protein purity for biotherapeutic research with confidence that data is accurate and reproducible.
For research use only. Not for use in diagnostic procedures.

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Molecular Cytogenetics

Fast, precise, and cost-effective targeted molecular karyotyping

Molecular cytogenetics plays an important role in the characterization of chromosome anomalies and is a critical component of current genetic studies including research into both constitutional disorders and cancer.

PerkinElmer is bringing the newest molecular techniques to cytogenetic laboratories. Our innovative methodologies support:

  • Increased detection rates
  • Faster results at lower costs
  • Streamlined processes
  • Support from sample-to-result

Oligonucleotide-based microarrays and bead-based multiplex BACs-on-Beads® products have been specifically designed, developed and validated by cytogeneticists for cytogeneticists performing molecular karyotyping.

For research use only. Not for use in diagnostic procedures.

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