PerkinElmer

Cancer Immunotherapy & Immunology

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Immuno-oncology has emerged as an exciting area of personalized medicine because of its tremendous potential to harness the powerful immune system to target and destroy cancer cells with few side effects, when targeted to the right tumor at the right time. Researchers are exploring the complex relationship between tumor cells and the immune system within the tumor microenvironment in order to discover new immuno-oncology targets and therapies.

Research Tools

Our cancer immunotherapy research solutions span the entire drug discovery workflow, from drug screening to studies in pre-clinical animal models to imaging of human tumor samples in clinical trials.

  • Immunoassays and reagents
  • Plate readers
  • Advanced multiplex tissue staining kits
  • Image analysis software
  • Quantitative pathology imaging systems
  • High content imaging and analysis
  • In Vivo imaging
  • Contract services

LANCE Detection Kit
LANCE Detection Kit

Kits and Reagents for Immuno-Oncology Research

Targeting immune checkpoint inhibitors, such as PD-1, PD-L1, and CTLA-4, has become pivotal in immunotherapy research, and so have monoclonal antibodies (mAbs), whether naked or conjugated with a chemotherapy agent or radioactive particle. Another area of active investigation is chimeric antigen receptor (CAR) T-cell therapy, where T cells are genetically programmed to attach to proteins on the surface of cancer cells. We offer a number of reagent technologies, radioactive and non-rad, for detection of key immuno-oncology targets.
Vectra 3 200 slide
Vectra 3 200 slide

Instrumentation for Immuno-Oncology Research

With our full suite of immuno-oncology products and solutions––including instrumentation and software for in vitro, ex vivo and in vivo models––we enable rapid and targeted discoveries in cancer immunotherapy.
Contract Research Services for Phenotyping In Situ
Contract Research Services for Phenotyping In Situ

Contract Services for Immuno-Oncology Research

Looking for an assay that’s not commercially available? Ask us about our custom services for immuno-oncology research including custom labeling of biomolecules, full assay development and transfer, and tissue imaging and analysis.

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IVIS Spectrum In Vivo Imaging System

IVIS SpectrumBL High-Throughput In Vivo Optical Imaging System

The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
Vectra image

Vectra 3.0 Automated Quantitative Pathology Imaging System

The Vectra® 3 automated quantitative pathology imaging system accurately detects and measures weakly expressed and overlapping biomarkers within a single H&E, IHC or IF intact FFPE tissue section or TMA to accelerate your cancer immunology research.
IVIS Spectrum In Vivo Imaging System

IVIS Spectrum In Vivo Imaging System

The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
Vectra Polaris with monitor

Vectra Polaris Automated Quantitative Pathology Imaging System

The Vectra® Polaris Automated Quantitative Pathology Imaging System integrates both multispectral imaging and automated slide scanning to better visualize, analyze, quantify, and phenotype immune cells in situ in FFPE tissue sections and TMAs.
1000x1000_Operetta

Operetta CLS High-Content Analysis System

Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

IVIS Lumina XRMS In Vivo Imaging System

Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
G4 Preclinical PET benchtop scanner with integrated X-ray

G4 PET/X-ray Preclinical Imaging System

Ultrasensitive and fast multimodal PET/X-ray imaging at your benchtop. The G-Platform offers and includes the G4 and G8 imaging systems.
IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

IVIS SpectrumCT In Vivo Imaging System

The IVIS® SpectumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

IVIS Lumina LT In Vivo Imaging System

The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

IVIS Lumina III In Vivo Imaging System

The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
Quantum GX2 microCT imaging system

Quantum GX2 microCT Imaging System

Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
Mantra benchtop

Mantra Quantitative Pathology Workstation

Mantra quantitative pathology workstation with inForm® image analysis software enables easy visualization, quantification and phenotyping of multiple types of immune cells simultaneously in intact FFPE tissue sections for cancer immunology research.
1000x1000_Opera_Phenix

Opera Phenix High-Content Screening System

The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
AlphaLISA immunoassay kits

α-tubulin AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for α-tubulin enables the detection and quantitation of human α-tubulin in tissue homogenates and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 478.00 GBP - 13450.00 GBP
In vivo Fluorescent Agents

IntegriSense 680 Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 
List Price : 632.00 GBP
AlphaLisa Analyte 2

BCL-2 (human), lyophilized (AlphaLISA)

Human BCL-2 standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA BCL-2 Detection Kit, but can be ordered separately.
List Price : 212.00 GBP
In vivo Fluorescent Agents

AngioSPARK 750 Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
List Price : 737.00 GBP
Amplification Diluent

TSA Tetramethylrhodamine Tyramide Reagent Pack, Reagents for 100-300 Slides

TSA® tetramethylrhodamine (TMR) reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra biotin in the localized area of the probe or antibody.
List Price : 394.00 GBP
In vivo Fluorescent Agents

Cat B 680 FAST Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.  
List Price : 571.00 GBP
AlphaLISA immunoassay kits

N-cadherin (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human N-cadherin enables the detection and quantitation of human N-Cadherin in tissue homogenates and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 315.00 GBP - 6890.00 GBP
AlphaLISA immunoassay kits

CD40 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human CD40 enables the quantitative determination of human cluster of differentiation 40 protein in serum, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 515.00 GBP - 7290.00 GBP
Amplification Diluent

TSA Fluorescein Reagent Pack

TSA® fluorescein reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra biotin in the localized area of the probe or antibody.
Price Range : 394.00 GBP - 1850.00 GBP
AlphaLISA immunoassay kits

PD-L1 (human) AlphaLISA Detection Kit

The AlphaLISA® Human PD-L1 Detection Kit is designed for detection and quantitation of Human PD-L1 (CD274/B7-H1) in immunoassay buffer, human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 477.00 GBP - 6690.00 GBP
Bioluminescent Oncology Cell Lines - Bioware

Bioware® Brite Cell Line HT29 Red-FLuc

Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
AlphaLISA immunoassay kits

IFN-β (human) AlphaLISA Detection Kit

The AlphaLISA® Human Interferon β (IFNβ) Detection Kit is designed for detection and quantitation of human IFNβ in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The analyte in this kit corresponds to the IFN-ß 1a subtype.
Price Range : 1040.00 GBP - 6930.00 GBP
AlphaLISA immunoassay kits

Mucin-16 (Ovarian carcinoma antigen CA125) (human) AlphaLISA Detection Kit

The AlphaLISA® Human Mucin-16 / Ovarian Carcinoma Antigen CA125 (CA125) Detection Kit is designed for detection and quantitation of human CA125 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1040.00 GBP - 6930.00 GBP
Bioluminescent Oncology Cell Lines - Bioware

Bioware® Brite Cell Line HCT116 Red-FLuc

Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
Bioluminescent Oncology Cell Lines - Bioware

Bioware® Brite Cell Line A549 Red-FLuc

Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.

EGF (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human EGF Detection Kit is designed for detection and quantitation of human epidermal growth factor in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 547.00 GBP - 7290.00 GBP
AlphaLISA immunoassay kits

VCAM-1 (human) AlphaLISA Detection Kit

The AlphaLISA® VCAM-1 Detection Kit is designed for detection and quantitation of Intracellular Adhesion Molecule 1 (VCAM-1) in cell culture media, serum, and plasma using a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 443.00 GBP - 6900.00 GBP
TSA Biotin System

TSA Biotin System

TSA® biotin detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra biotin in the localized area of the probe or antibody.
Price Range : 261.00 GBP - 870.00 GBP

MMP-3 (human) AlphaLISA Detection Kit, 5,000 Assay Points

The AlphaLISA® Human Matrix Metalloproteinase-3 (MMP3) Detection Kit is designed for detection and quantitation of human MMP3 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The kit was designed to detect both MMP3 and pro-MMP3.
Price Range : 2000.00 GBP - 15630.00 GBP

MMP-9 (human) AlphaLISA Detection Kit

The AlphaLISA® Human Matrix Metalloproteinase-9 (MMP9) Detection Kit is designed for detection and quantitation of human MMP9 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The kit was designed to detect both MMP9 and pro-MMP9.
Price Range : 1040.00 GBP - 6930.00 GBP
AlphaLISA immunoassay kits

TIM-3 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human TIM-3 enables the quantitative determination of human T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 412.00 GBP - 9890.00 GBP
AlphaLISA immunoassay kits

TGF-β1 (human) AlphaLISA Biotin-Free Detection Kit

The AlphaLISA® Human TGF-β1 Biotin-Free Detection Kit is designed for the quantitative detection of human TGF-β1 in serum, cell culture medium, and other samples types using a homogeneous (no wash steps, no separation steps) assay. The biotin-free kit is compatible with high-biotin culture media and other sample types that contain high levels biotin.
Price Range : 306.00 GBP - 6690.00 GBP
AlphaLISA immunoassay kits

HLA-E (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human HLA-E enables the quantitative determination of human MHC class I antigen E (HLA-E) in buffered solution, cell culture supernatants, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 515.00 GBP - 9890.00 GBP
In vivo Fluorescent Agents

IntegriSense 750 Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications. 
List Price : 632.00 GBP
Protein

BMP-9 (human), lyophilized (AlphaLISA)

Human BMP-9 standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human BMP-9 Detection Kit, but can also be ordered separately.
List Price : 203.00 GBP

Collagen IV (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human collagen IV enables the quantitative determination of collagen IV in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 297.00 GBP - 6510.00 GBP

E-Cadherin (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human E-cadherin enables the detection and quantitation of human E-cadherin in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 306.00 GBP - 6690.00 GBP
AlphaLISA immunoassay kits

TNFα (cynomolgus) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for cynomolgus TNFα enables the quantitative determination of cynomolgus tumor necrosis factor alpha in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 297.00 GBP - 6510.00 GBP
1X Plus Amplification Diluent

1X Plus Amplification Diluent

This patented, ready-to-use amplification diluent has been optimized specifically for Opal and TSA® Plus immunohistochemistry protocols. Used in conjunction with Opal or TSA Plus, the diluent facilitates signal amplification localized to the area of the target.
List Price : 298.00 GBP
Bioluminescent Oncology Cell Lines - Bioware

Bioware® Brite Cell Line HepG2-Red-FLuc

Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
AlphaLISA immunoassay kits

MMP-8 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human MMP-8 enables the detection and quantitation of human MMP-8 in human serum or cell culture medium using a homogeneous AlphaLISA assay (no wash steps). The kit was designed to detect both MMP8 and pro-MMP8.
Price Range : 306.00 GBP - 6690.00 GBP
Opal 4 Lymphocyte Kit, 50 slides

Opal 4 Lymphocyte Kit

The Opal 4 Tumor Lymphocyte Kit enables phenotyping of helper T cells, cytotoxic T cells and B cells within intact FFPE tissue sections.
List Price : 1090.00 GBP

EGFR (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human EGFR Detection Kit is designed for detection and quantitation of human Epidermal Growth Factor Receptor in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 547.00 GBP - 7290.00 GBP
AlphaLisa Analyte 2

Human Programmed Cell Death Protein 1 (PD-1), 0.3 µg (lyophilized)

Human Programmed Cell Death Protein 1 (PD-1) standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human PD-1 Detection Kit, but can be ordered separately.
List Price : 170.00 GBP
PerkinElmer

Anti-DNP AP Conjugate

Anti-DNP antibody conjugated to alkaline phosphatase
List Price : 293.00 GBP

RediJect 2-DG Fluorescent Imaging Probe (Explorer kit)

XenoLight RediJect 2-DeoxyGlucosone (DG) 750 is a fluorescent imaging probe for in vivo targeting of tumors that typically exhibit elevated glucose uptake rate in comparison to surrounding tissues. To achieve maximum glucose targeting and enhanced tumor uptake, the probe has been designed to contain four 2-DG molecules per dye molecule. 
List Price : 229.00 GBP
PerkinElmer

TSA Fluorescein System

TSA® fluorescein detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra fluorescein in the localized area of the probe or antibody.
Price Range : 335.00 GBP - 588.00 GBP

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