PerkinElmer

Cancer Immunotherapy & Immunology

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Immuno-oncology has emerged as an exciting area of personalized medicine because of its tremendous potential to harness the powerful immune system to target and destroy cancer cells with few side effects, when targeted to the right tumor at the right time. Researchers are exploring the complex relationship between tumor cells and the immune system within the tumor microenvironment in order to discover new immuno-oncology targets and therapies.

Research Tools

Our cancer immunotherapy research solutions span the entire drug discovery workflow, from drug screening to studies in pre-clinical animal models to imaging of human tumor samples in clinical trials.

  • Immunoassays and reagents
  • Plate readers
  • Advanced multiplex tissue staining kits
  • Image analysis software
  • Quantitative pathology imaging systems
  • High content imaging and analysis
  • In Vivo imaging
  • Contract services

LANCE Detection Kit
LANCE Detection Kit

Kits and Reagents for Immuno-Oncology Research

Targeting immune checkpoint inhibitors, such as PD-1, PD-L1, and CTLA-4, has become pivotal in immunotherapy research, and so have monoclonal antibodies (mAbs), whether naked or conjugated with a chemotherapy agent or radioactive particle. Another area of active investigation is chimeric antigen receptor (CAR) T-cell therapy, where T cells are genetically programmed to attach to proteins on the surface of cancer cells. We offer a number of reagent technologies, radioactive and non-rad, for detection of key immuno-oncology targets.
Vectra 3 200 slide
Vectra 3 200 slide

Instrumentation for Immuno-Oncology Research

With our full suite of immuno-oncology products and solutions––including instrumentation and software for in vitro, ex vivo and in vivo models––we enable rapid and targeted discoveries in cancer immunotherapy.
Contract Research Services for Phenotyping In Situ
Contract Research Services for Phenotyping In Situ

Contract Services for Immuno-Oncology Research

Looking for an assay that’s not commercially available? Ask us about our custom services for immuno-oncology research including custom labeling of biomolecules, full assay development and transfer, and tissue imaging and analysis.

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Vectra Polaris with monitor

Vectra Polaris Automated Quantitative Pathology Imaging System

The Vectra® Polaris Automated Quantitative Pathology Imaging System integrates both multispectral imaging and automated slide scanning to better visualize, analyze, quantify, and phenotype immune cells in situ in FFPE tissue sections and TMAs.
1000x1000_Operetta

Operetta CLS High-Content Analysis System

Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
Vectra_ImageA

Vectra 3.0 Automated Quantitative Pathology Imaging System

The Vectra® 3 automated quantitative pathology imaging system accurately detects and measures weakly expressed and overlapping biomarkers within a single H&E, IHC or IF intact FFPE tissue section or TMA to accelerate your cancer immunology research.
IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

IVIS Lumina III In Vivo Imaging System

The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
Quantum GX2 microCT imaging system

Quantum GX2 microCT Imaging System

Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

IVIS Lumina LT In Vivo Imaging System

The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

IVIS SpectrumCT In Vivo Imaging System

The IVIS® SpectumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
IVIS Spectrum In Vivo Imaging System

IVIS SpectrumBL High-Throughput In Vivo Optical Imaging System

The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
Mantra benchtop

Mantra Quantitative Pathology Workstation

Mantra quantitative pathology workstation with inForm® image analysis software enables easy visualization, quantification and phenotyping of multiple types of immune cells simultaneously in intact FFPE tissue sections for cancer immunology research.
IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

IVIS Lumina XRMS In Vivo Imaging System

Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
G4 Preclinical PET benchtop scanner with integrated X-ray

G4 PET/X-ray Preclinical Imaging System

Ultrasensitive and fast multimodal PET/X-ray imaging at your benchtop. The G-Platform offers and includes the G4 and G8 imaging systems.
1000x1000_Opera_Phenix

Opera Phenix High-Content Screening System

The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
IVIS Spectrum In Vivo Imaging System

IVIS Spectrum In Vivo Imaging System

The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
AlphaLISA immunoassay kits

TGF-β1 (human) AlphaLISA Detection Kit

The AlphaLISA® Human TGF-β1 Detection Kit is designed for detection and quantitation of human TGF-β1 (hTGF-β1) in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows negligible cross-reactivity with human hTGF-β2 and hTGF-β3.
Price Range : 449.00 GBP - 6500.00 GBP
AlphaLISA immunoassay kits

EGFR (human) AlphaLISA Detection Kit

The AlphaLISA® EGFR Detection Kit is designed for detection and quantitation of human Epidermal Growth Factor Receptor (EGFR) in cell culture media, human serum, and other sample types using a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 449.00 GBP - 6500.00 GBP
AlphaLISA immunoassay kits

MMP-12 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human MMP-12 enables the detection and quantitation of human matrix metalloproteinase-12 in serum or cell culture medium using a homogeneous AlphaLISA assay (no wash steps). The kit was designed to detect both MMP12 and pro-MMP12.
Price Range : 288.00 GBP - 6300.00 GBP

TGF-β1 (human) AlphaLISA Biotin-Free Detection Kit

The AlphaLISA® Human TGF-β1 Biotin-Free Detection Kit is designed for the quantitative detection of human TGF-β1 in serum, cell culture medium, and other samples types using a homogeneous (no wash steps, no separation steps) assay. The biotin-free kit is compatible with high-biotin culture media and other sample types that contain high levels biotin.
Price Range : 288.00 GBP - 6300.00 GBP
AlphaLISA immunoassay kits

4-1BBL (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human 4-1BBL enables the quantitative determination of 4-1BB ligand in buffer, cell culture media, cell supernatants, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 505.00 GBP - 7150.00 GBP
PerkinElmer

TSA Biotin Reagent Pack

TSA® biotin reagent pack, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. These reagents amplify by depositing extra biotin in the localized area of the probe or antibody.
Price Range : 675.00 GBP - 2350.00 GBP
AlphaLISA assay principle

FGF23 (Human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human FGF23 enables the quantitative determination of human FGF23 in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The kit demonstrated no cross reactivity to FGF21 and very low reactivity to Mouse FGF23.
Price Range : 309.00 GBP - 6310.00 GBP
In vivo Fluorescent Agents

AngioSense 680EX Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.
List Price : 514.00 GBP
LANCE Detection Kit

PIP Collagen (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra PIP Collagen Detection Kit is designed for detection and quantitation of human PIP collagen in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 499.00 GBP - 6660.00 GBP

PD-L1 (human) AlphaLISA Detection Kit

The AlphaLISA® Human PD-L1 Detection Kit is designed for detection and quantitation of Human PD-L1 (CD274/B7-H1) in immunoassay buffer, human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 449.00 GBP - 6300.00 GBP
AlphaLISA immunoassay kits

LAG-3 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human LAG-3 enables the quantitative determination of human lymphocyte-activation gene 3 (LAG-3) in serum, buffered solution, and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 485.00 GBP - 9300.00 GBP
AlphaLisa Analyte 2

Vimentin (human), liquid (AlphaLISA)

Human vimentin standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human Vimentin Detection Kit, but can also be ordered separately.
List Price : 261.00 GBP
AlphaLISA immunoassay kits

MMP-9 (human) AlphaLISA Detection Kit

The AlphaLISA® Human Matrix Metalloproteinase-9 (MMP9) Detection Kit is designed for detection and quantitation of human MMP9 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The kit was designed to detect both MMP9 and pro-MMP9.
Price Range : 982.00 GBP - 6520.00 GBP
PerkinElmer

TSA Plus TMR

TSA® Plus tetramethylrhodamine (TMR) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra TMR in the localized area of the probe or antibody.
Price Range : 322.00 GBP - 1410.00 GBP

CTLA-4 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) enables the quantitative determination of human CTLA-4 in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 388.00 GBP - 9300.00 GBP
AlphaLISA immunoassay kits

SCF (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human SCF enables the quantitative determination of stem cell factor (SCF; KIT-ligand) in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 280.00 GBP - 6120.00 GBP
Bioluminescent Oncology Cell Lines - Bioware

Bioware® Brite Cell Line HT29 Red-FLuc

Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.

ErbB2 (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human ErbB2 (HER2) Detection Kit is designed for detection and quantitation of human ErbB2 in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 514.00 GBP - 6860.00 GBP
LANCE Detection Kit

EGF-EGFR LANCE Ultra TR-FRET Binding Kit

This kit is designed for the detection of binding activity between Human EGF and EGFR using a homogeneous LANCE Ultra TR-FRET assay. This assay can facilitate the design and development of therapeutics which competitively inhibit EGF/EGFR interaction.
Price Range : 499.00 GBP - 6660.00 GBP
AlphaLISA immunoassay kits

N-cadherin (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human N-cadherin enables the detection and quantitation of human N-Cadherin in tissue homogenates and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 296.00 GBP - 6490.00 GBP
AlphaLISA immunoassay kits

MMP-8 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human MMP-8 enables the detection and quantitation of human MMP-8 in human serum or cell culture medium using a homogeneous AlphaLISA assay (no wash steps). The kit was designed to detect both MMP8 and pro-MMP8.
Price Range : 288.00 GBP - 6300.00 GBP
AlphaLISA immunoassay kits

PD-L2 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human PD-L2 enables the quantitative determination of human programmed death 1 ligand 2 (PD-L2) in serum and over-expressing cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 485.00 GBP - 6860.00 GBP

CD276 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human CD276 enables the quantitative determination of human Cluster of Differentiation 276 (CD276, B7-H3) in serum, buffered solution, and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 485.00 GBP - 9300.00 GBP

ß-NGF (human) AlphaLISA Detection Kit

The AlphaLISA® Human Beta-Nerve Growth Factor (β-NGF) Detection Kit is designed for detection and quantitation of human β-NGF in cell culture medium and serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 982.00 GBP - 6520.00 GBP

VCAM-1 (human) AlphaLISA Detection Kit

The AlphaLISA® VCAM-1 Detection Kit is designed for detection and quantitation of Intracellular Adhesion Molecule 1 (VCAM-1) in cell culture media, serum, and plasma using a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 417.00 GBP - 6500.00 GBP
PerkinElmer

TSA Plus Cyanine 3

TSA® Plus Cyanine 3 (Cy3) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. This kit amplifies by depositing extra Cy3 in the localized area of the probe or antibody.
Price Range : 133.00 GBP - 1410.00 GBP
TSA Plus DNP (HRP)System

TSA Plus DNP (HRP)

TSA® Plus DNP (HRP) detection kit, for amplification of signal in immunohistochemistry (IHC), immunofluorescence (IF) or in situ hybridization protocols. The deposited DNP is detected using an anti-DNP hroseradish peroxidase, with appropriate substrate.
Price Range : 169.00 GBP - 302.00 GBP
AlphaLISA immunoassay kits

CD117 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human CD117 enables the quantitative determination of human CD117 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 280.00 GBP - 6120.00 GBP
LANCE Detection Kit

BCL-2 (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human BCL-2 Detection Kit is designed for detection and quantitation of human Bcl-2 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 514.00 GBP - 6860.00 GBP
AlphaLISA immunoassay kits

TIM-3 (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human TIM-3 enables the quantitative determination of human T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 388.00 GBP - 9300.00 GBP

EGF (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human EGF Detection Kit is designed for detection and quantitation of human epidermal growth factor in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 514.00 GBP - 6860.00 GBP
AlphaLisa Analyte 2

p53 (human), lyophilized (AlphaLISA)

p53 standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human p53 Detection Kit, but can be ordered separately.
List Price : 194.00 GBP
AlphaLisa Analyte 2

B7-H5/VISTA (human), lyophilized (AlphaLISA)

Human VISTA standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human VISTA Detection Kit, but can also be ordered separately.
List Price : 261.00 GBP
Bioluminescent Oncology Cell Lines - Bioware

Bioware® Brite Cell Line B16F10 Red-FLuc

Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.
AlphaLISA immunoassay kits

Mesothelin (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human mesothelin enables the quantitative determination of human mesothelin (CAK1, ERC) in serum, buffered solution, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 485.00 GBP - 9300.00 GBP
Protein

Fibrinogen (human), lyophilized (LANCE)

Human fibrinogen standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Human fibrinogen TR-FRET Detection Kit, but can also be ordered separately.
List Price : 191.00 GBP
Bioware Bioluminescent Oncology Cell LInes

Bioware® Brite Cell Line 4T1-Red-FLuc-GFP

Our bioluminescent light-producing oncology cell lines are labeled with luciferase or dual labeled with luciferase and fluorescent reporters (GFP) for in vivo studies.

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