PerkinElmer

Epigenetics Research

OF

The study of gene expression is opening new doors for drug discovery. Our epigenetics solutions include cellular detection kits and epigenetic assays for readers, writers, and erasers – allowing you to characterize multiple targets, shorten assay development time, and accelerate drug discovery.

Benefits of epigenetics kits and assays include:

  • Flexibility: Work with peptide or full-length protein substrates, or endogenous histones in biochemical or cell-based format
  • Sensitivity: Robust and reproducible detection, even at low enzyme concentrations
  • Specificity: Reagents highly specific for the mark of interest
  • Simplicity: One-well, no-wash assay platforms amenable to automation and HTS
  • Validated: Detailed, ready-to-use protocols for over 30 epigenetic enzyme assays

Drugs that can alter cellular traits have particular importance for conditions related to epigenetic modification, including cancer, mental illness, and heart disease. As knowledge of gene expression in disease states advances, so too does the possibility for epigenetic drugs.

Whether you need an epigenetics kit or validated assay, our suite of epigenetics research reagents offers a faster, more efficient path in the race to identify promising epigenetic drug candidates.

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Product Type
  • Instruments (4)
  • Reagents (101)
Assay Target
  • Histone H2A (1)
  • Histone H3 (9)
  • Histone H4 (1)
Target Species
  • Human (1)
Application
  • Epigenetics (49)
  • Mobility Shift (3)
  • Molecular Biology (41)
  • Protein Analysis & Detection (6)
  • Protein-protein interactions (5)
Therapeutic Area
  • Epigenetics (11)
Product Brand Name
  • AlphaLISA (34)
  • AlphaPlex (1)
  • DELFIA (5)
  • EasyTide (20)
  • EnSpire (1)
  • EnVision (1)
  • LabChip EZ Reader (5)
  • LANCE Ultra (14)
  • NEN Radiochemicals (21)
  • Victor (1)
  • ViewLux (1)
Detection Method
  • Absorbance (3)
  • Alpha (37)
  • DELFIA TRF (5)
  • Fluorescence (3)
  • Fluorescence Polarization (3)
  • Luminescence (3)
  • Radiometric (41)
  • Time-Resolved Fluorescence (TRF) (22)
  • TR-FRET (14)
Molecular Modification
  • Acetylation (12)
  • GlcNAc (1)
  • Glycosidation (1)
  • Methylation (25)
  • Total (1)
  • Unmodified (4)
Sample Type
  • Enzyme (3)
Antibody Conjugates
  • Anti-acetyl-lysine (1)
  • Anti-Acetyl-Lysine (1)
  • Anti-H3 (C-term) (1)
  • Anti-H3K27ac (2)
  • Anti-H3K27me2 (1)
  • Anti-H3K27me2-1 (1)
  • Anti-H3K27me3 (2)
  • Anti-H3K36me2 (2)
  • Anti-H3K4 (3)
  • Anti-H3K4me1-2 (2)
  • Anti-H3K9/H3K27 (1)
  • Anti-H3K9/K27 (1)
  • Anti-H3K9ac (2)
  • Anti-H3K9me2 (2)
  • Anti-H3R2me (1)
  • Anti-H4K20me1 (1)
  • Anti-H4R3me (2)
  • Anti-methyl arginine (1)
  • Anti-methyl-Arg (1)
  • Anti-O-GlcNAc (1)
  • Anti-O-linked-GlcNAc (1)
  • Anti-p53K382ac (2)
  • Streptavidin (3)
Radioisotope
  • P-32 (41)
Radionuclide
  • 32P (40)
Nucleotide
  • ATP (10)
  • CTP (4)
  • dATP (5)
  • dCTP (4)
  • dGTP (2)
  • dTTP (3)
  • GTP (4)
  • NAD (2)
  • pCp (1)
  • UTP (6)
Fluorophore
  • Eu-N1 (1)
  • Eu-N1-ITC (2)
  • Eu-W1024 (14)
  • Sm-N1 (1)
  • Tb-N1 (1)
Label Position
  • alpha (30)
  • gamma (8)
  • Specifically Labeled (3)
Buffer
  • Tricine (18)
  • Tricine with stabilizer and dye (20)
Assay points(200-50,000)
  • 100 (9)
  • 500 (11)
  • 5000 (11)
Assay Target Class
  • Histone (11)
Automation Compatible
  • Yes (57)
Concentration
  • 10 mCi/mL (22)
  • 20 mCi/mL (2)
  • 40 mCi/mL (1)
  • 5 mCi/mL (2)
Experimental Type
  • In vitro (54)
Format
  • Microplates (55)

"Epigenetics Research" 1-50 of 105 Products and Services

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ViewLux uHTS Microplate Imager

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is available outside the EU. Please contact your local representative to discuss alternative products.

EnVision 2105 multimode plate reader

EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

VictorX_ImageA_320px

VICTOR Multilabel Plate Reader

The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
EnSpire Alpha Plate Reader

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

dTTP, [α-32P]- 800Ci/mmol 10mCi/ml EasyTide, 250 µCi

Thymidine triphosphate (deoxythymidine triphosphate), labeled on the alpha phosphate group with 32P.
List Price : 192.00 GBP

LANCE Ultra Europium-anti-methyl-Histone H3 Lysine 4 (H3K4me1-2)

Europium-labeled monoclonal antibody recognizing human H3 mono- and di-methylated at lysine 4 (H3K4me1-2). For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2140.00 GBP - 5360.00 GBP

DELFIA Eu-Labeling kit (Eu-N1-ITC chelate), 0.2mg

DELFIA® Europium labeling kit for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 333.00 GBP

AlphaLISA Anti-methyl Histone H3 Arginine 2 (H3R2me) Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human Histone H3 that is methylated at arginine 2 (H3R2me). These beads can be used for AlphaLISA no-wash epigenetic writer and eraser assays.
Price Range : 874.00 GBP - 15910.00 GBP
Adenosine 5 Triphosphate 250 µCi

ATP, [γ-32P]- 3000Ci/mmol 5mCi/ml Lead, 250 µCi

Adenosine triphosphate, labeled on the gamma phosphate group with 32P
List Price : 143.00 GBP

dCTP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide

Deoxycytidine triphosphate, labeled on the alpha phosphate group with 32P.
Price Range : 117.00 GBP - 277.00 GBP

CTP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide, 250 µCi

Cytidine triphosphate, labeled on the alpha phosphate group with 32P
List Price : 186.00 GBP

ATP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide , 250 µCi

Adenosine triphosphate, labeled on the alpha phosphate group with 32P.
List Price : 166.00 GBP

Anti-methyl-Histone H3/H4 Arginine (H3/H4Rme pan) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human Histone H3 and H4 methylated on arginine residues. This bead can be used to create AlphaLISA no-wash epigenetic writer and eraser assays.
Price Range : 891.00 GBP - 15910.00 GBP

Anti-Histone H3 (C-term) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads designed to capture Histone H3 in a homogeneous AlphaLISA assay for DOT1L. Use in conjunction with biotinylated anti-H3K79me2 (AL148).
Price Range : 874.00 GBP - 15910.00 GBP

DELFIA Eu-N1 ITC chelate & Eu standard, 1 mg

DELFIA® Europium labeling chelate and Europium standard for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 1320.00 GBP

LANCE Ultra Europium-anti-tri-methyl-Histone H3 Lysine 27 (H3K27me3) Antibody

Europium-labeled monoclonal antibody recognizing human Histone H3 tri-methylated at lysine 27 (H3K27me3). For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2140.00 GBP - 5360.00 GBP
Adenosine 5 Triphosphate 250 µCi

UTP, [α-32P]- 3000Ci/mmol 10mCi/ml Lead

Uridine triphosphate, labeled on the alpha phosphate group with 32P.
Price Range : 174.00 GBP - 450.00 GBP

Anti-methyl-Histone H3 Lysine 9 (H3K9me2) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human histone H3 di-methylated at lysine 9 (H3K9me2). These beads can be used for no-wash AlphaLISA epigenetic writer and eraser assays.
Price Range : 874.00 GBP - 15910.00 GBP

AlphaLISA Anti-di-methyl-Histone H3 Lysine 36 (H3K36me2) Acceptor Beads (for peptide substrate only)

AlphaLISA® Acceptor beads conjugated to an antibody against human histone H3 di-methylated at lysine 36 (H3K36me2). These beads can be used for no-wash AlphaLISA epigenetic writer and eraser assays.
Price Range : 934.00 GBP - 15910.00 GBP

Anti-methyl-Histone H3 Lysine 4 (H3K4me1-2) AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human histone H3 mono- or di-methylated at lysine 4 (H3K4me1-2). These beads can be used for no-wash AlphaLISA epigenetic writer and eraser assays.
Price Range : 874.00 GBP - 15910.00 GBP
PerkinElmer

HDAC (Histone Deacylase) Substrate B, for LabChip EZ Reader

Fluorescently-labelled Substrate A peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
List Price : 442.00 GBP
PerkinElmer

HDAC (Histone Deacylase) Substrate A, for LabChip EZ Reader

Fluorescently-labelled Substrate A peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
List Price : 455.00 GBP
PerkinElmer

AlphaLISA Cell-Histone Buffer Set

Pre-formulated buffer for cell-based Alpha epigenetic assays.
Price Range : 525.00 GBP - 4130.00 GBP

AlphaLISA Biotinylated Anti-Histone H3 (C-ter) Antibody, 200 µg

Biotinylated antibody against the C-terminal end of human histone H3, for use in Alpha no-wash epigenetic assays using full-length histone H3 as substrate.
List Price : 6120.00 GBP

LANCE Ultra Europium-anti-di-methyl-Histone H3 Lysine 36 (H3K36me2) Antibody

Europium-labeled monoclonal antibody recognizing human Histone H3 di-methylated at lysine 36 (H3K36me2). For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2190.00 GBP - 5360.00 GBP
Adenosine 5 Triphosphate 250 µCi

NAD, [32P]- 800Ci/mmol 5mCi/ml Lead

Nicotinamide Adenine Dinucleotide (NAD) 32P is labeled on the adenylate phosphate
Price Range : 537.00 GBP - 1200.00 GBP
Adenosine 5 Triphosphate 250 µCi

ATP, [γ-32P]- 3000Ci/mmol 10mCi/ml Lead

Adenosine triphosphate, labeled on the gamma phosphate group with 32P
Price Range : 122.00 GBP - 282.00 GBP
AlphaLISA Cellular Epigenetics kits

AlphaLISA Tri-Methyl-Histone H3 Lysine 27 (H3K27me3) Cellular Detection Kit

This kit is designed for the detection of tri-methylated Histone H3 Lysine 27 (H3K27me3) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 428.00 GBP - 7620.00 GBP

AlphaLISA Anti-unmodified Histone H3 Lysine 9/Lysine 27 (H3K9/K27) Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human Histone H3 that is unmodified at lysine 9 and lysine 27. These beads can be used for AlphaLISA no-wash epigenetic eraser assays.
Price Range : 874.00 GBP - 15910.00 GBP

LANCE Ultra Europium-anti-di/mono-methyl-Histone H3 Lysine 27 (H3K27me2-1) Antibody

Europium-labeled monoclonal antibody recognizing human Histone H3 mono- and di-methylated at lysine 27 (H3K27me2-1). For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2140.00 GBP - 5360.00 GBP
AlphaLISA Cellular Epigenetics kits

AlphaLISA Acetylated Histone H3 Lysine 9 (H3K9ac) Cellular Detection Kit

This kit is designed for the detection of acetylated Histone H3 Lysine 9 (H3K9ac) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 428.00 GBP - 7620.00 GBP
AlphaLISA Cellular Epigenetics kits

AlphaLISA Di-Methyl-Histone H3 Lysine 4 (H3K4me2) Cellular Detection Kit

This kit is designed for the detection of di-methylated Histone H3 Lysine 4 (H3K4me2) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 428.00 GBP - 7620.00 GBP

ATP, [γ-32P]- 3000Ci/mmol 10mCi/ml EasyTide

Adenosine triphosphate, labeled on the gamma phosphate group with 32P.
Price Range : 117.00 GBP - 270.00 GBP

LANCE Ultra Europium-anti-methyl-Histone H3/H4 Arginine (H3/H4Rme pan) Antibody

Europium-labeled monoclonal antibody recognizing human Histone H3 and H4 methylated arginine residues. For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2140.00 GBP - 5350.00 GBP
PerkinElmer

SureFire Ultra Activation Buffer C (50X)

Extra activation buffer for the AlphaLISA SureFire Ultra pSTAT4 assay. This buffer is already included in the AlphaLISA SureFire Ultra pSTAT4 kit, but can also be ordered separately.
Price Range : 76.00 GBP - 400.00 GBP

UTP, [α-32P]- 3000Ci/mmol 10mCi/ml EasyTide

Uridine triphosphate, labeled on the alpha phosphate group with 32P.
Price Range : 166.00 GBP - 461.00 GBP

AlphaLISA Anti-acetyl-p53 Lysine 382 (p53K382ac) Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human p53 that is acetylated at lysine 382 (p53K382ac). These beads can be used for no-wash AlphaLISA epigenetic writer and eraser assays.
Price Range : 874.00 GBP - 15910.00 GBP

Biotin-anti-H3K79me2 antibody

Biotinylated antibody against human histone H3 that is dimethylated on Lysine 79. This antibody is intended for use in AlphaLISA® no-wash epigenetic assays using DOT1L methyltransferase with oligonucleosome substrates.
Price Range : 874.00 GBP - 15910.00 GBP

AlphaLISA Biotin-anti-Histone H4 Antibody

AlphaLISA® biotinylated monoclonal antibody recognizing the amino-terminal end of human histone H4. Broad species cross-reactivity is expected based on sequence similarity. This product is designed to be used with AlphaLISA® Epigenetics Acceptor beads to detect modified full-length histone H4 in homogeneous AlphaLISA assays.
Price Range : 681.00 GBP - 6120.00 GBP

AlphaLISA Anti-di/mono-methyl-Histone H3 Lysine 27 (H3K27me2-1) Acceptor Beads

AlphaLISA® Acceptor beads conjugated to an antibody against human histone H3 mono- or di-methylated at lysine 27 (H3K27me2-1). These beads can be used for no-wash AlphaLISA epigenetic writer and eraser assays.
Price Range : 874.00 GBP - 15910.00 GBP
Adenosine 5 Triphosphate 250 µCi

dATP, [α-32P]- 3000Ci/mmol 10mCi/ml Lead

Deoxyadenosine triphosphate, labeled on the alpha phosphate group with 32P
Price Range : 143.00 GBP - 349.00 GBP
AlphaPlex-545-antibody-bead2

Anti-unmodified H3K4 AlphaPlex-545 Acceptor Beads

AlphaPlex-545 (Terbium) Acceptor beads conjugated to antibody against human Histone H3 that is unmodified (H3K4), for use in Alpha no-wash multiplexing epigenetic assays.
Price Range : 918.00 GBP - 16690.00 GBP

dCTP, [α-32P]- 800Ci/mmol 10mCi/ml EasyTide

Deoxycytidine triphosphate, labeled on the alpha phosphate group with 32P.
List Price : 126.00 GBP

ATP, [γ-32P]- 6000Ci/mmol 10mCi/ml EasyTide

Adenosine triphosphate, labeled on the gamma phosphate group with 32P.
Price Range : 166.00 GBP - 353.00 GBP

LANCE Ultra Europium-anti-O-linked-GlcNAc Antibody

Europium-labeled monoclonal antibody recognizing O-linked n-acetylglucosamine (O-linked GlcNAc). For use in LANCE® Ultra post-translational modification assays.
Price Range : 2140.00 GBP - 5350.00 GBP
AlphaLISA Cellular Epigenetics kits

AlphaLISA unmodified Histone H3 Lysine 4 (H3K4) Cellular Detection Kit

This kit is designed to be used as a control for the AlphaLISA Epigenetic Cellular Detection Kits, through detection of unmodified Histone H3 Lysine 4 (H3K4) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 428.00 GBP - 7620.00 GBP

dATP, [α-32P]- 6000Ci/mmol 20mCi/ml EasyTide

Deoxyadenosine triphosphate, labeled on the alpha phosphate group with 32P.
Price Range : 154.00 GBP - 353.00 GBP
Adenosine 5 Triphosphate 250 µCi

Deoxyadenosine 5`-triphosphate, 3`-[α-32P]-, 250 µCi

3’ dATP (Cordycepin) is used in 3' end labeling of DNA using terminal transferase (TdT). It is a chain terminator, because it is deoxy- (missing an oxygen) at the 3’ position. It is often used in place of ddATP.
List Price : 397.00 GBP
AlphaLISA Cellular Epigenetics kits

AlphaLISA Acetylated-Histone H3 Lysine 27 (H3K27ac) Cellular Detection Kit

This kit is designed for the detection of acetylated Histone H3 Lysine 27 (H3K27ac) in cell lysates using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 428.00 GBP - 7620.00 GBP

dCTP, [α-32P]- 6000Ci/mmol 20mCi/ml EasyTide

Deoxycytidine triphosphate, labeled on the alpha phosphate group with 32P.
Price Range : 154.00 GBP - 353.00 GBP

"Epigenetics Research" 1-50 of 105 Products and Services

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