PerkinElmer

High Throughput and Phenotypic Screening

OF

Complete solutions for high-throughput and phenotypic screening – together, this spells discovery.

To get drugs to market that much sooner, you need to accelerate your workflow, upstream and downstream. Our screening solutions are a crucial component in that effort: State-of-the art imaging and detection instruments, assay technologies, reagents, versatile automation systems, and powerful informatics solutions working together to ensure consistent, accurate, physiologically relevant results – with one-of-a-kind analytics to wrest more meaning from your findings. Amplify your phenotypic or target-based screens to identify hits and lead compounds in small and focused or high-throughput volumes by using of complete suite of instrument, reagents and informatics solutions:

  • Screening assays for molecular targets
  • High content screening using cellular models
  • High content analysis of microtissues and 3D cell culture
  • Orthogonal testing and secondary screening
  • Selectivity screening
  • Large volume data capture and rapid analysis

High Throughput Screening
High Throughput Screening

High Throughput Screening

From validated assays to verified workflows, our HTS solutions for target-based screening enhance efficiency in your lab and confidence in your results.
Screening Data Analysis
Screening Data Analysis

Data Analysis

With the large volumes of data generated by high-throughput and phenotypic screening, you need software solutions that can aggregate and interpret your results. We offer scalable platforms that make it easy to access and manage all relevant data for enhancing the speed and efficiency in drug discovery.

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Operetta CLS High Content Analysis Instrument

Operetta CLS High-Content Analysis System

Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.

EnSpire Alpha Plate Reader

The EnSpire Alpha Plate Reader provides proven Alpha technology to your lab at an affordable price and from the Alpha detection leader.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

EnVision_Alone_Left_Angle

EnVision 2105 Multimode Plate Reader

The EnVision 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

ViewLux uHTS Microplate Imager

The ViewLux® is the gold standard, ultra high-speed microplate imager, ideal for high throughput screening of compound libraries requiring the ultimate in speed, reliability and high quality data.

The ViewLux uHTS microplate imager is available outside the EU. Please contact your local representative to discuss alternative products.

EnSight multimode plate-reader

EnSight Multimode Plate Reader

The EnSight multimode plate reader combines labeled & image-based cytometry technologies in a single benchtop platform. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.

Opera Phenix High-Content Screening System

The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
JANUS G3 Btx Pro-Plus

Flexible JANUS® G3 Automated Workstations

The JANUS® G3 Automated workstations include a portfolio of precision liquid handling solutions that provide adaptability in throughput, plate capacity and dynamic volume range to meet your current and future automation needs.

EnSpire Multimode Plate Reader

EnSpire® Multimode Plate Reader is designed to meet the demands of multi-user research environments, providing high performance technology and flexibility for a range of applications without compromising sensitivity. Combine this with our expertise and portfolio of reagents, PerkinElmer offers an unrivaled solution to your application needs.

EnSpire Plate Reader is available outside the EU. Please contact your local representative for further details.

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VICTOR Multilabel Plate Reader

The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
JANUS-G3-Standard-8Tip-Varispan-and-MDT-Workstation

JANUS G3 Varispan + MDT Automated Workstation

The JANUS® G3 Automated Workstation offers multiple pipetting technologies on a single instrument platform. The instrument consists of a modular platform and combines a flexible 4- or 8-tip Varispan™ arm with 96- or 384-channel Modular Dispense Technology™ (MDT) dispense head, providing an automated liquid handling solution with flexibility in throughput, plate capacity, and dynamic volume range.
JANUS G3 Btx Pro-Plus

JANUS G3 BioTx Pro Plus Workstation

The JANUS® G3 Bio Tx Pro Plus offers full walk-away automation for high-throughput process development, enabling more data from precious starting materials and limited resources.
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JANUS G3 MDT Automated Workstation

The JANUS® G3 MDT Automated Workstation offers multiple pipetting technologies on a single instrument platform. The instrument consists of an expanding modular platform and a 96- or 384-channel Modular Dispense Technology (MDT) dispense head, and provides an automated liquid handling solution with flexibility in throughput, plate capacity, and dynamic volume range.

C-Peptide (mouse/rat) AlphaLISA Detection Kit

The AlphaLISA® Mouse/Rat Connecting Peptide (C-Peptide) Detection Kit is designed for detection and quantitation of mouse or rat C-Peptide in buffered solution in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1880.00 GBP - 14710.00 GBP
AlphaLISA SureFire Ultra kits

Phospho-TrkA (Tyr674/675)/phospho-TrkB (Tyr706/707) AlphaLISA SureFire Ultra Assay Kit

The AlphaLISA® SureFire® Ultra™ p-TrkA (Tyr674/675)/p-Trk-B (Tyr706/707) assay is a sandwich immunoassay for quantitative detection of phospho-TrkA (phosphorylated on Tyr674/675) and/or pTrkB (phosphorylated on residues Tyr706/707) in cellular lysates using Alpha Technology.
Price Range : 316.00 GBP - 19060.00 GBP
AlphaLISA immunoassay kits

GAD67 (Human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for GAD67 enables the quantitative determination of human glutamate decarboxylase 67 (hGAD67) in serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows less than 5% cross reactivity with mouse GAD67. Cross-reactivity with other species has not tested.
Price Range : 499.00 GBP - 15970.00 GBP

CCL5/RANTES (mouse) AlphaLISA Detection Kit

The AlphaLISA® Mouse C-C Motif Chemokine 5 / Regulated Upon Activation Normal T-Cell Expressed, and Secreted (CCL5/RANTES) Detection Kit is designed for detection and quantitation of mouse CCL5/RANTES in serum, bronchial lavage fluid (BALF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 2010.00 GBP - 14710.00 GBP

IL-28B (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human IL-28B Detection Kit is designed for detection and quantitation of human IL-28B in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 576.00 GBP - 7680.00 GBP
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-VEGF Receptor 2 (Tyr1175) Assay Kit

The AlphaLISA® SureFire® Ultrap-VEGF Receptor 2 (Tyr1175) assay is a sandwich immunoassay for quantitative detection of phospho-VEGFR Receptor 2 (phosphorylated on Tyr1175) in cellular lysates using Alpha Technology.
Price Range : 316.00 GBP - 18330.00 GBP

LANCE Ultra Europium-anti-di/mono-methyl-Histone H3 Lysine 27 (H3K27me2-1) Antibody

Europium-labeled monoclonal antibody recognizing human Histone H3 mono- and di-methylated at lysine 27 (H3K27me2-1). For use in LANCE® Ultra epigenetic writer and eraser assays.
Price Range : 2140.00 GBP - 5360.00 GBP
AlphaLisa Analyte 2

Nidogen-1 (human), lyophilized (AlphaLISA)

Nidogen-1 standard, lyophilized, for use in running standard curves in AlphaLISA no-wash immunoassays. This standard is already provided in the AlphaLISA Human Nidogen-1 Detection Kit, but can be ordered separately.
List Price : 155.00 GBP
Alpha SureFire Ultra Multiplex kits

Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (S473) (Eu) + Total Akt1 (Tb) Kit

The Alpha SureFire® Ultra™ HV Multiplex p-Akt 1/2/3 (Ser473) + Total Akt 1 assay kit is used to measure both the phosphorylation (Ser473) and total levels of endogenous Akt in cellular lysates. The kit measures phosphorylation on Ser473 of Akt 1/2/3, and total levels of Akt 1 only. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure Akt (Ser473) activation by either recombinant or endogenous receptors, and can be applied to primary cells.
Price Range : 542.00 GBP - 31470.00 GBP

AlphaScreen PhosphoSensor Kit

Antibody-free assay for kinase activity via dectection of phosphorylated protein or peptide substrate.
Price Range : 248.00 GBP - 1860.00 GBP

GM-CSF (mouse) AlphaLISA Detection Kit

The AlphaLISA® Mouse Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Detection Kit is designed for detection and quantitation of mouse GM-CSF in serum, bronchial lavage fluid (BALF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 1880.00 GBP - 14710.00 GBP

ULight anti-mouse IgG

ULight™ labeled anti-mouse IgG antibody for LANCE® TR-FRET assays. The anti-mouse IgG antibody is a purified goat polyclonal antibody.
Price Range : 276.00 GBP - 6990.00 GBP
SureFire principle

AlphaScreen SureFire ALK (p-Tyr1586) Assay Kit

The AlphaScreen® SureFire® p-ALK (Tyr1586) assay is a sandwich immunoassay for quantitative detection of phospho-ALK (phosphorylated on Tyr1586) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 965.00 GBP - 10430.00 GBP

CellCarrier (384-well, black with optically clear bottom, PDL-coated, with lid)

384-well poly-D-lysine (PDL-coated) microplate with black walls and clear bottom for high content imaging, high content screening, and cell-based assays.
Price Range : 817.00 GBP - 3160.00 GBP

LANCE Ultra ULight™-PLK (Ser137) peptide

ULight™-labeled synthetic peptide containing the amino acid residues surrounding Ser137 of polo-like kinase (PLK). The ULight-PLK peptide can be phosphorylated at Ser137 by a variety of kinases including Aurora A, PAK2, MSK1, PKA and PKC. Peptide core motif : RRRSLLE
Price Range : 142.00 GBP - 516.00 GBP
AlphaLISA immunoassay kits

BDNF (human) AlphaLISA Detection Kit

AlphaLISA no-wash immunoassay kit for detection and quantitation of Brain Derived Neurotrophic Factor (BDNF) in serum, cell culture supernatants, and other samples.
Price Range : 449.00 GBP - 6500.00 GBP
AlphaPlex-545-antibody-bead2

Anti-FLAG AlphaPlex-545 (Tb) Acceptor beads

AlphaPlex-545 (Terbium) Acceptor beads conjugated to anti-FLAG antibody, for use in Alpha no-wash multiplexing assays.
Price Range : 380.00 GBP - 15580.00 GBP

AlphaScreen GST Detection Kit

AlphaScreen® no-wash assay kit containing Streptavidin Donor beads and Anti-GST conjugated AlphaScreen Acceptor beads. This kit contains enough reagents to run 500 wells in 384-well format, using a 25 µL reaction volume.
Price Range : 116.00 GBP - 8900.00 GBP
AlphaLISA immunoassay kits

Ghrelin (active) (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for active human ghrelin enables the quantitative determination of active ghrelin in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
Price Range : 388.00 GBP - 11630.00 GBP
SureFire principle

AlphaScreen SureFire IkBalpha (p-Ser32/Ser36) Assay Kit

The AlphaScreen® SureFire® p-IκBα (Ser32/36) assay is a sandwich immunoassay for quantitative detection of phospho-IκBα (phosphorylated on Ser32/36) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 965.00 GBP - 10430.00 GBP
AlphaLISA immunoassay kits

IL-1ß (rat) AlphaLISA Detection Kit

The AlphaLISA® Rat Interleukin 1ß (IL-1ß) Detection Kit is designed for detection and quantitation of rat IL-1ß in bronchial lavage fluid (BALF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
Price Range : 982.00 GBP - 6520.00 GBP
Assay schematic for LANCE <em>Ultra</em> TR-FRET cellular phosphorylation detection assay

Phospho-SMAD3 (Ser423/425) LANCE Ultra TR-FRET Cellular Detection Kit

LANCE Ultra phospho-SMAD3 (Ser423/425) kits are designed for the detection of SMAD3 (phosphorylated at residue S423/S425) in cell lysates using a simple, homogeneous LANCE Ultra assay (no wash steps). This assay is compatible with both adherent and suspension cells.
Price Range : 892.00 GBP - 4000.00 GBP
SureFire principle

AlphaScreen SureFire Akt 1/2 (p-Ser473) Assay Kit

The AlphaScreen® SureFire® p-Akt 1/2 (Ser473) assay is a sandwich immunoassay for quantitative detection of phospho-Akt 1/2 (phosphorylated on Ser473) in cellular lysates using Alpha Technology. Please note that an AlphaScreen Protein A kit, which contains the Alpha Beads necessary to run this assay, needs to be purchased separately in addition to the AlphaScreen SureFire kit.
Price Range : 965.00 GBP - 10430.00 GBP

TAU (human) AlphaLISA Detection Kit

The AlphaLISA® Human Microtubule-associated Protein Tau (TAU) Detection Kit is designed for detection and quantitation of human TAU in cerebrospinal fluid (CSF), buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The antibodies used in the kit correspond to clone numbers BT2 and Tau 12.
Price Range : 1880.00 GBP - 14710.00 GBP
AlphaLISA immunoassay kits

IL-8 (bovine/ovine) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for bovine IL-8 enables the detection and quantitation of bovine IL8 (bIL8) in serum, buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). This kit is 100% cross-reactive with Ovine IL-8.
Price Range : 449.00 GBP - 6490.00 GBP
Protein

IL-28B (human), lyophilized (LANCE)

Human IL-28B standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Human IL-28B Detection Kit, but can also be ordered separately.
List Price : 174.00 GBP
AlphaLISA SureFire Ultra kits

AlphaLISA SureFire Ultra p-STAT4 (Tyr693) Assay Kit

The AlphaLISA® SureFire® Ultra p-STAT4 (Tyr693) assay is a sandwich immunoassay for quantitative detection of endogenous STAT4 phosphorylated at Tyr693 in cellular lysates using Alpha Technology.
Price Range : 316.00 GBP - 18330.00 GBP
LANCE Detection Kit

IL17F (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human IL-17F Detection Kit is designed for detection and quantitation of human interleukin 17 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 514.00 GBP - 6860.00 GBP

CellCarrier (384-well, black with optically clear bottom, sterile TC-treated, with lid)

384-well tissue culture-treated (TC-treated) polystyrene microplate with black walls and clear bottom for cell-based assays, high content analysis, and microscopic viewing.
Price Range : 627.00 GBP - 2350.00 GBP

IL-12/p40 (human) LANCE Ultra TR-FRET Detection Kit

The LANCE® Ultra Human IL-12/p40 Detection Kit is designed for detection and quantitation of human interleukin-12/p40 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
Price Range : 514.00 GBP - 6860.00 GBP
Assay principle of Alpha Terbium SureFire Ultra assay

Phospho-SLP-76 (Ser376) Terbium SureFire Ultra Detection Kit

The Alpha SureFire® Ultra™ Multiplex kits allow the rapid, sensitive, and quantitative detection of two phosphoprotein targets in each well of an assay plate. This kit can be used in combination with any AlphaLISA SureFire Ultra assay to detect phospho-SLP-76 (Ser376) in a multiplexed assay.
Price Range : 226.00 GBP - 13610.00 GBP
Receptor-expressing cell lines

Bombesin BB3 AequoScreen cell line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
Receptor-expressing cell lines

ValiScreen Vasopressin V1a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
AlphaLISA immunoassay kits

Laminin (human) AlphaLISA Detection Kit

The AlphaLISA® immunoassay kit for human laminin enables the detection and quantitation of human laminin in human serum, plasma, lysates, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows no cross-reactivity with human IL-28A, IL-29, and Mouse Laminin.
Price Range : 288.00 GBP - 6300.00 GBP
AlphaLISA immunoassay kits

GDNF (human) AlphaLISA Detection kit

AlphaLISA no-wash immunoassay kit for detection and quantitation of human GDNF (glial cell-derived neurotrophic factor) in serum, plasma, cell culture supernatants, and other samples.
Price Range : 417.00 GBP - 6490.00 GBP
Receptor-expressing cell lines

ValiScreen Neuropeptide S NPS (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
AlphaLISA SureFire Ultra kits

Phospho-Cofilin (Ser3) AlphaLISA SureFire Ultra Detection Kit

The AlphaLISA® SureFire® Ultra p-Cofilin (Ser3) assay is a sandwich immunoassay for quantitative detection of phospho-cofilin (phosphorylated on Ser3) in cellular lysates using Alpha Technology.
Price Range : 316.00 GBP - 19060.00 GBP
PerkinElmer

FCGR3A/CD16A (176Phe/F158) (human) AlphaLISA Detection Kit

This kit is designed for the detection of binding activity between human FCGR3A (176Phe) and human IgG Fc fragment using a homogeneous AlphaLISA® assay (no wash steps). This assay can facilitate the design and development of antibody therapetics by using competitive binding.
Price Range : 377.00 GBP - 6860.00 GBP

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