PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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"Receptor Ligand Binding" 1-50 of 545 Products and Services

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UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
Receptor-expressing cell lines

ValiScreen Melanocortin MC5 (mouse) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

Insulin (porcine), Receptor Grade, [125I]TyrA14]

Porcine insulin, labeled with 125I on tyrosineA14. This product is receptor-grade, and was developed for receptor-binding assays. Insulin binds and activates insulin receptor (IR), a tyrosine kinase receptor involved in glucose uptake.
Price Range : 1170.00 GBP - 2280.00 GBP

DELFIA Eu-Labeling kit (Eu-N1-ITC chelate), 0.2mg

DELFIA® Europium labeling kit for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 333.00 GBP
Adenosine 5 Triphosphate 250 µCi

Deltorphin II (2-D-Ala), [Tyrosyl-3,5-3H]

Deltorphin II, tritiated at the tyrosyl-3,5 position. Deltorphin II is a selective δ opioid receptor (DOPR) agonist.
Price Range : 730.00 GBP - 3090.00 GBP
PerkinElmer

Membrane Target Systems: Melanocortin MC5 (mouse) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP
Alpha Bungarotoxin

Iodo-(-)-Cyanopindolol, [125I]

Iodo-(-)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.
Price Range : 1100.00 GBP - 1800.00 GBP
Alpha Bungarotoxin

Recombinant Protein A, [125I]-, 100µCi (3.7MBq)

Recombinant Protein A, labeled with 125I. I-125 labeled Protein A can be used as a general tracer to capture antibodies in radioimmunoassays (RIAs).
List Price : 940.00 GBP
Alpha Bungarotoxin

Insulin-like Growth Factor-I (human, recombinant), 125I

Insulin-like growth factor 1 (IGF-1), labeled with 125I. IGF-1 acts as an agonist at the IGF-1 receptor, a receptor tyrosine kinase, that plays a role in growth, cancer, and aging. IGF-1 also binds the insulin receptor (IR), another receptor tyrosine kinase involved in glucose homeostasis, diabetes, and cancer.
Price Range : 685.00 GBP - 1680.00 GBP
Alpha Bungarotoxin

Triiodothyronine, ([125I]-T3), Specific Activity: 135-165 µCi/µg

Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Price Range : 685.00 GBP - 1730.00 GBP
PerkinElmer

Membrane Target Systems: Chemoattractant C5a (human varient) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human chemoattractant C5a (human varient) receptor, 400 units.
List Price : 569.00 GBP
Receptor-expressing cell lines

ValiScreen Prostanoid DP (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Glycerol 3 Phosphate, ammonium salt, L-[14C(U)]-

DICLOFENAC SODIUM[PHENYLACETIC ACID RING- U-14C]

Diclofenac sodium, labeled with C-14 on the phenylacetic acid ring. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that acts as an antagonist at peroxisome prolifeator-activated receptor gamma (PPAR-γ or PPARG).
List Price : 1870.00 GBP
Alpha Bungarotoxin

2'-deoxycytidine-5'-triphosphate, 5-[125I]Iodo-

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
List Price : 1770.00 GBP
Adenosine 5 Triphosphate 250 µCi

Nisoxetine Hydrochloride, [N-Methyl-3H]-, 250µCi (9.25MBq)

Nisoxetine hydrochloride, tritiated on the N-methyl group. Nisoxetine is a potent and selective inhibitor of the norepinephrine transporter.
List Price : 1810.00 GBP

UniFilter-96 GF/B PEI Coated Plates - Case of 50

PEI-coated GF/B glassfibre filter-bottom 96-well microplate, for receptor binding and cell harvesting assays using a vacuum manifold.
List Price : 589.00 GBP
Alpha Bungarotoxin

Vasoactive Intestinal Polypeptide (human, porcine, rat), [125I]

Vasoactive intestinal polypeptide (VIP), labeled with 125I. VIP binds vasoactive intestinal peptide receptors VPAC1 and VPAC2, a group of GPCRs that are potential drug targets for nervous and endocrine disorders and several types of cancer.
Price Range : 975.00 GBP - 2130.00 GBP
Adenosine 5 Triphosphate 250 µCi

CP 55940, [Side Chain-2,3,4-3H(N)]

CP 55,940, tritiated on the side chain-2,3-4 position. CP 55,940 is a synthetic cannabinoid that acts as a full agonist at both cannabinoid CB1 and CB2 receptors, and can also upregulate serotonin 5-HT2A receptors.
Price Range : 535.00 GBP - 3930.00 GBP
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-2C (e) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

Angiotensin II, [125I]-Sar1, Ile8], 50µCi

Angiotensin II, labeled with 125I on the tyrosine residue. Angiotensin II is an endogenous agonist of angiotensin II receptors, a class of GPCRs important in vasoconstriction.
List Price : 2320.00 GBP
PerkinElmer

Uncoated PS Imaging Beads, 2G

Uncoated PS SPA beads have been shown to interact with primary phosphate groups in nucleotides (e.g. ATP) and oligonucleotides, DNA, and RNA. Membrane preparations can also be coupled to the beads.
List Price : 314.00 GBP
Receptor-expressing cell lines

ValiScreen Nociceptin NOP (ORL1) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

RX 821002, [6,7-3H(N)]-

RX 821002, tritiated at the 6,7 position. RX 821002 acts as an antagonist at α2-adrenoceptors.
List Price : 1640.00 GBP
PerkinElmer

DELFIA® L*R binding buffer concentrate (10x), 250 mL

Buffer for DELFIA® time-resolved fluorescence (TRF) ligand binding assays.
List Price : 337.00 GBP

UniFilter-96 GF/C, White 96-well Barex Microplate with 1.2 µm poresize GF/C filter

GF/C glassfibre filter-bottom 96-well microplate, for cell harvesting assays using a vacuum manifold.
List Price : 532.00 GBP
Adenosine 5 Triphosphate 250 µCi

Ro 15-1788, [N-Methyl-3H]

Ro 15-1788 (flumazenil), tritiated on the N-methyl group. Ro 15-1788 acts as a selective benzodiazepine antagonist.
Price Range : 519.00 GBP - 3890.00 GBP
Receptor-expressing cell lines

ValiScreen Melanocortin MC3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

Neurotensin, [125I]Tyr3]

Neurotensin, labeled with 125I on the tyrosine 3 residue. Neurotensin functions as an agonist at neurotensin receptors. It is known to induce analgesia, hypothermia and increased locomotor activity. Neurotensin is also involved in the regulation of dopamine.
Price Range : 1020.00 GBP - 2130.00 GBP
PerkinElmer

Membrane Target Systems: Somatostatin sst5 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 569.00 GBP
Alpha Bungarotoxin

Guanosine 3`,5`-cyclic Phosphoric Acid, 2`-O-succinyl Iodotyrosine Methyl Ester, [125I]

cGMP, labeled with 125I on the tyrosine methyl ester group. I-125 labeled cGMP can be used as a tracer for radioimmunoassays to detect levels of endogenous cGMP in a sample.
Price Range : 385.00 GBP - 6100.00 GBP
Alpha Bungarotoxin

MIP-1α (human, recombinant), [125I]

Human recombinant macrophage inflammatory protein 1-alpha (MIP-1α; CCL3), labeled with 125I. MIP-1α is a cytokine involved in acute inflammation, and binds C-C chemokine receptors CCR1, CCR4, and CCR5.
Price Range : 746.00 GBP - 3060.00 GBP
PerkinElmer

ProfilerPro Kinase Peptide Substrate 33, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 33 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 455.00 GBP
PerkinElmer

PDE Substrate iFL-cGMP, for LabChip EZ Reader

Fluorescently-labelled cGMP for Phosphodiesterase Assays (Enyzme inhibiton, target discovery, lead optimization)
List Price : 555.00 GBP
PerkinElmer

Membrane Target Systems: Adenosine A1 (rat) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with rat adenosine A1 receptor, 400 units.
List Price : 569.00 GBP
Adenosine 5 Triphosphate 250 µCi

5-Hydroxytryptamine Creatinine Sulfate, [1,2-3H(N)]

5-Hydroxytryptamine Creatinine Sulfate (Serotonin, 5-HT), tritiated at the 1,2 position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors.
Price Range : 597.00 GBP - 1610.00 GBP
Adenosine 5 Triphosphate 250 µCi

Bradykinin, [2,3-Prolyl-3,4-3H(N)]

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.
Price Range : 1410.00 GBP - 3210.00 GBP
Adenosine 5 Triphosphate 250 µCi

Diltiazem, cis-(+)-[N-Methyl-3H]

cis-(+)-Diltiazem, tritiated at the N-methyl position. Diltiazem is a non-DHP calcium channel blocker.
Price Range : 1310.00 GBP - 2940.00 GBP
Glycerol 3 Phosphate, ammonium salt, L-[14C(U)]-

COUMARIN, 7-ETHOXY, [3- 14C]-

50 µCi quantities of 7-ETHOXY-[3-14C]-Coumarin are available for your research.
List Price : 1550.00 GBP
Adenosine 5 Triphosphate 250 µCi

Dihydroxyphenylethylamine (Dopamine), 3,4-[Ring-2,5,6-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the ring-2,5,6- position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.
Price Range : 512.00 GBP - 1190.00 GBP
PerkinElmer

WGA PVT PEI TYPE B 500 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.
List Price : 511.00 GBP
PerkinElmer

WGA PVT SPECIAL 25 X 500 MG

Wheat germ agglutinin (WGA), PEI-coated SPA beads, for proximity-based radiometric scintillation assays. The treatment of PVT-WGA SPA beads with positively charged polyethyleneimine (PEI) blocks potential non-specific binding sites on the SPA bead surface.
List Price : 9500.00 GBP
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 9, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
List Price : 985.00 GBP
Alpha Bungarotoxin

Goat anti-rabbit IgG, [125I]

Anti-rabbit immunoglobulin G (IgG), labeled with 125I. I-125 labeled anti-rabbit IgG can be used as a tracer to capture rabbit IgG antibodies in radioimmunoassays (RIAs).
Price Range : 852.00 GBP - 998.00 GBP
Receptor-expressing cell lines

ValiScreen N-formyl Peptide (FPRL1) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

"Receptor Ligand Binding" 1-50 of 545 Products and Services

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