check quantity


5-hydroxytryptamine (5-HT, or serotonin) labeled with tritium. It is a naturally occurring neurotransmitter which is tied to positive mood, certain involuntary muscle control, and countless other functions.

You successfully added item(s) to your cart

Part Number
Unit Size
List Price
Your Price
250 µCi
492.00 GBP
1 mCi
1800.00 GBP
Buy Now

Please enter valid quantity

Please login to add favorites


Detail Information

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in the central nervous system (CNS). 5-HT binds 5-HT serotonin receptors to regulate smooth muscle in the cardiovascular system and the GI tract and enhances platelet aggregation. These receptors are part of a group of serotonin G-protein coupled receptors (GPCRs) found in the central and peripheral nervous systems. 5-HT receptors are the pharmacological target of many antidepressants, antipsychotic, anti-migraine, and other pharmaceutical drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1167:

  1. Derek N. Middlemiss, John R. Fozard, 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site, In European Journal of Pharmacology, Volume 90, Issue 1, 1983, Pages 151-153.
  2. Derek N. Middlemiss, Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol, In European Journal of Pharmacology, Volume 101, Issues 3–4, 1984, Pages 289-293.
  3. Piñeyro Graciela, Castanon, Nathalie, Hen, René, Blier, Pierre, Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice, NeuroReport, Volume 7, Issue 1, 1995, Pages 353-359.


Detection Method Radiometric
Label Position Generally Labeled
Molecular Weight 290.0
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Receptor Type 5-Hydroxytryptamine
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 1 mCi
Resources, Events & More
  • All


Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.