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Angiotensin II, [125I]-Sar1, Ile8], 50µCi

Angiotensin II, labeled with 125I on the tyrosine residue. Angiotensin II is an endogenous agonist of angiotensin II receptors, a class of GPCRs important in vasoconstriction.

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NEX248050UC
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Detail Information

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX248:

  1. Linares, A., Couling, L. E., Carrera, E. J., Speth, R. C. (2016), Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors. J. Vis. Exp. (112), e53866.
  2. Hwang, B.H., Chan, P., Peters, T. (2004), Angiotensin II receptor binding in the locus ceruleus of spontaneously hypertensive rats and Wistar-Kyoto rats: a quantitative autoradiographic study with references to hypertension and cardiac/testicular hypertrophy, J Biomed Sci, 11 (3): 331-338.

Specifications

Detection Method Radiometric
Fresh Lot Days Second Monday of each month
Label Position Nominally Labeled
Product Brand Name NEN Radiolabeled Ligands
Radioisotope I-125
Radionuclide 125I
Receptor Type Angiotensin
Shipping Condition Ambient
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area Angiogenesis, Cardiovascular
Unit Size 50 µCi
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Using the NENSure Packaging System from PerkinElmer

Since 1985, the unique NENSure system has set the standard for radiochemical packaging. Based on proven performance over millions of shipments, the system provides: Ease of use, Safe storage of unused product and Reduced radiation exposure. Many NEN brand research products, including 32P-, 33P-, 35S-, 3H-, 14C- and 125I-labeled compounds, are packaged in the NENSure System, as are most radionuclides.

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