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IVIS Spectrum In Vivo Imaging System

The IVIS® Spectrum in vivo imaging system uses a novel patented optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.

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An optimized set of high efficiency filters and spectral un-mixing algorithms lets you take full advantage of bioluminescent and fluorescent reporters across the blue to near infrared wavelength region. It also offers single-view 3D tomography for both fluorescent and bioluminescent reporters that can be analyzed in an anatomical context using our Digital Mouse Atlas or registered with our multimodality module to other tomographic technologies such as MR, CT or PET.

For advanced fluorescence pre-clinical imaging, the IVIS Spectrum has the capability to use either trans-illumination (from the bottom) or epi-illumination (from the top) to illuminate in vivo fluorescent sources. 3D diffuse fluorescence tomography can be performed to determine source localization and concentration using the combination of structured light and trans illumination fluorescent images. The instrument is equipped with 10 narrow band excitation filters (30nm bandwidth) and 18 narrow band emission filters (20nm bandwidth) that assist in significantly reducing autofluorescence by the spectral scanning of filters and the use of spectral unmixing algorithms. In addition, the spectral unmixing tools allow the researcher to separate signals from multiple fluorescent reporters within the same animal.

Features & Benefits

  • High-sensitivity in vivo imaging of fluorescence and bioluminescence
  • High throughput (5 mice) with 23 cm field of view
  • High resolution (to 20 microns) with 3.9 cm field of view
  • Twenty eight high efficiency filters spanning 430 – 850 nm
  • Supports spectral unmixing applications
  • Ideal for distinguishing multiple bioluminescent and fluorescent reporters
  • Optical switch in the fluorescence illumination path allows reflection-mode or transmission-mode illumination
  • 3D diffuse tomographic reconstruction for both fluorescence and bioluminescence
  • Ability import and automatically co-register CT or MRI images yielding a functional and anatomical context for your scientific data.
  • NIST traceable absolute calibrations
  • Gas anesthesia inlet and outlet ports
  • Class I Laser Product

Disclaimer:  For research use only. Not for use in diagnostic procedures.


Imaging Modality Optical Imaging
Optical Imaging Classification Bioluminescence imaging, Fluorescence Imaging
Portable No
Product Brand Name IVIS

Resources, Events & More

All (46)
Resource Type File Name File Format
Brochure 3D Multimodality Imaging: See disease in all its dimensions PDF  2 MB
Brochure IVIS Spectrum (Product Note) PDF  3 MB
Product Note Living Image® Software PDF  734 KB
Product Note RAS-4 Rodent Anesthesia System PDF  562 KB
Application Note Advances in 3D Optical Imaging Quantification and Sensitivity PDF  3 MB
Application Note Cerenkov Imaging of Radioisotopes in IVIS systems PDF  2 MB
Application Note Stem Cell Research and Regenerative Medicine PDF  1 MB
Technical Note Adaptive Fluorescence Background Subtraction PDF  1 MB
Technical Note AutoExposure PDF  1 MB
Technical Note DLIT 1 Setup PDF  1 MB
Technical Note DLIT 2 Topography PDF  1 MB
Technical Note DLIT 3 Reconstruction PDF  3 MB
Technical Note Determine Saturation PDF  1 MB
Technical Note Drawing ROIs PDF  669 KB
Technical Note FLIT 2 Topography PDF  748 KB
Technical Note FLIT 3 Reconstruction PDF  2 MB
Technical Note High Resolution Images PDF  1 MB
Technical Note Image Overlay 2D PDF  472 KB
Technical Note Image Overlay 3D PDF  731 KB
Technical Note Intraperitoneal Injections PDF  189 KB
Technical Note Kinetic Analysis of Bioluminescent Sources PDF  1 MB
Technical Note Loading Groups of Images PDF  751 KB
Technical Note Multimodal Co-registration Using the Quantum GX, G8 PET/CT and IVIS Spectrum Imaging Systems (TechNote) PDF  4 MB
Technical Note Spectral Unmixing PDF  4 MB
Technical Note Subject ROI PDF  2 MB
Technical Note Transillumination 1 Setup PDF  918 KB
Technical Note Transillumination 2 Raster Scan PDF  2 MB
Technical Note Transillumination 3 Normalized PDF  802 KB
Technical Note Well Plate Quantification Library PDF  879 KB
Technical Note Working with Image Math PDF  911 KB
Technical Note Working with Imaging Wizard PDF  4 MB
Poster Multimodality workflow for assessing drug distribution & efficacy in breast cancer xenografts PDF  908 KB
Featured Publication Note Comparative study reveals better far-red fluorescent protein for whole body imaging PDF  441 KB
Featured Publication Note Imaging in CRISPR/Cas9 Applications PDF  443 KB
Featured Publication Note Imaging of tumor clones with differential liver colonization PDF  241 KB
Flyer Comparison of IVIS Imaging Systems PDF  1 MB
Citations Library View peer reviewed publications using PerkinElmer's In Vivo Imaging systems Link
Event StemConn 2017 Link
Software Downloads In Vivo Imaging Software Downloads Link
Video Article JoVE Video Articles Link
Webinars In Vivo Imaging Today and Tomorrow: How multimodal imaging is driving translational research - View On Demand Link
Webinars In Vivo Multimodal Imaging: Combining Functional and Anatomical Modalities to Enrich Your Data - View On Demand Link
Webinars View our complete list of in vivo webinars available on demand Link
Webinars In vivo imaging of drug-induced liver injury using NIR fluorescent imaging agents - View On Demand Link
Webinars Optical and microCT Imaging of Bacteria, Viruses, and Tumors - View On Demand Link
Webinars Application of Cerenkov Luminescence for Brown Adipose Tissue Imaging and In vivo Photochemistry - View On Demand Link