PerkinElmer
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Mantra Quantitative Pathology Workstation

Mantra quantitative pathology workstation with inForm® image analysis software enables easy visualization, quantification and phenotyping of multiple types of immune cells simultaneously in intact FFPE tissue sections for cancer immunology research.

Part Number CLS140089
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For research use only. Not for use in diagnostic procedures.

Detail Information

Every Cancer Tells a Story If You Have the Tools To Read It

Mantra is a compact workstation which enables you to phenotype immune cells in situ in solid tumors using multiplexed biomarkers.

Traditional methods like flow cytometry and next-generation sequencing allow you to phenotype and quantify immune cells in homogenized samples, but you lose critical spatial information and context. Meanwhile, standard pathological analyses can deliver morphology data but do not allow the analysis of complex phenotypes.

With multispectral imaging, you can phenotype and quantify immune cells from images of FFPE tissue sections, maintaining tissue architecture, cellular spatial relationships and morphological context. This capability available on the Mantra provides spatial information, allowing for a better understanding of the role and types of immune cells within both the tumor and the tumor microenvironment so that new cancer immunotherapy treatments may be identified and researched.

The Mantra workstation is ideal for labs getting started with multispectral imaging and for assay development, allowing higher throughput systems such as Vectra® Polaris to be freed up. It incorporates multispectral imaging technology, image acquisition and analysis with the inForm® software, and can be used with a variety of stains including PerkinElmer's Opal reagent kits.

Stain, Image, Analyze, and Phenotype Immune Cells In-Situ with Phenoptics

The Mantra workstation is a part of PerkinElmer’s integrated Phenoptics workflow solution for immuno-oncology which includes staining reagents, imaging systems, and image analysis software.

Together, the in situ multiplexed biomarker staining, imaging systems such as Mantra, and image analysis software enable cell phenotypes to be simultaneously studied in solid tumors and their microenvironment. That allows for the quantification of cancer-immune interactions, revealing which disease mechanism is at play—to help discover and validate biomarkers and providing better data to support research into potential subpopulation stratification methodologies.

Key Features:

  • Visualizes, analyzes, quantifies and phenotypes immune cells in situ in solid tissues
  • Ideal for getting started with multispectral imaging or for assay development to free up a higher throughput system such as the Vectra Polaris
  • Intuitive workflow optimized for the research pathologist
  • Compact system that fits on your benchtop
  • Eye-piece for easy visual checking of work as you go
  • Automated Brightfield and multichannel fluorescence (up to 7 colors) capabilities
  • Liquid crystal tuneable filter (LCTF) technology
  • Phenochart whole slide viewer for slide navigation provides context for identification of regions of interest within a digital pathology workflow
  • Automatic identification of specific tissue types using integrated inForm analysis software
  • Supports PerkinElmer’s Phenoptics workflow solution for cancer immunology research

Specifications

21 CFR Part 11 Compatible No
Detection Method Fluorescence, Brightfield
Interface Usb
Light Source Metal Halide Lamp (Fl), Led (Bf)
Optical Imaging Classification Brightfield, Fluorescence
Portable No
Product Brand Name Mantra
Research Areas Cancer Research
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Regulatory Compliance Certification

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Product Information Bulletin

Scientific Paper